机构：[1]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[2]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[3]Department of Obstetric and Gynecologic, West China Second University Hospital, Sichuan University, Chengdu 610041, China[4]Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, China[5]Department of Pathology, West China Hospital of Sichuan University, 37 Guoxue Street, Chengdu, Sichuan 610041, China四川大学华西医院[6]Department of Obstetric and Gynecologic, Henan Provincial People’s Hospital, Zhengzhou, Henan 450003, China[7]Department of Gynecological Oncology, Second People’s Hospital of Sichuan (Sichuan Cancer Hospital), Chengdu, Sichuan 610041, China四川省肿瘤医院
Lin28B, a homologue of Lin28, represses biogenesis of let-7 microRNAs with a role in tumorigenesis and is considered a potential therapeutic target for various human cancers. The aim of the study was to identify the clinical significance of Lin28B in gastric adenocarcinoma (GAC). We examined the expression of Lin28B in 97 human gastric cancer samples with 32 samples of non-dysplastic tissues by immunohistochemistry. In the 97 GAC cases, 42 were with high Lin28B expression. The expression levels of Lin28B proteins in GAC were higher than in corresponding adjacent normal tissues (P=0.001). Significant correlations were noted between Lin28B expression and lymph node status (P=0.005), TNM stage (P < 0.001), tumor invasion (P=0.036), and differentiation (P=0.001) of GAC patients. The Kaplan-Meier estimates showed a negative correlation of overall 5-year survival rate with Lin28B expression where higher expression resulted in poorer prognosis in GAC. In univariate analysis, lymph node metastasis, TNM stage, serosal invasion, Lin28B expression as well as differentiation grade could predict the prognosis of GAC patients (P=0.002, P < 0.001, P=0.003, P < 0.001, P=0.001, respectively). Multivariate analysis revealed that the expression level of Lin28B (P < 0.001), TNM stage (P < 0.001) as well as differentiation grade (P < 0.001) were the three potential independent prognostic factors in our study [Hazard ratio (HR)=2.108 and P=0.017, HR=1.994 and P=0.018, HR=1.939 and P=0.046, respectively]. Our findings point to the prognostic role of Lin28B in GAC, and indicate Lin28B as a potential therapeutic target of GAC patients.
基金：
Science Grant from Science and Technology Department of Sichuan Province, China (2012SZ0136) to Shanling Liu, also Supported by the Science Grant from National Natural Science Foundation of China (81270660) to He Wang, and the Young Scientific Innovation Team in Neurological Disorders grant 2011JTD0005 from the Department of Science and Technology of Sichuan Province, China
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[2]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[3]Department of Obstetric and Gynecologic, West China Second University Hospital, Sichuan University, Chengdu 610041, China[4]Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, China
通讯作者：
通讯机构：[1]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[2]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[3]Department of Obstetric and Gynecologic, West China Second University Hospital, Sichuan University, Chengdu 610041, China[4]Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, China[*1]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[*2]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China
推荐引用方式(GB/T 7714)：
Qian Hu,Jing Peng,Weiping Liu,et al.Lin28B is a novel prognostic marker in gastric adenocarcinoma.[J].International journal of clinical and experimental pathology.2014,7(8):5083-92.
APA：
Qian Hu,Jing Peng,Weiping Liu,Xiaoli He,Ling Cui...&He Wang.(2014).Lin28B is a novel prognostic marker in gastric adenocarcinoma..International journal of clinical and experimental pathology,7,(8)
MLA：
Qian Hu,et al."Lin28B is a novel prognostic marker in gastric adenocarcinoma.".International journal of clinical and experimental pathology 7..8(2014):5083-92
