机构：[1]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[2]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[3]Department of Obstetric and Gynecologic, West China Second University Hospital, Sichuan University, Chengdu 610041, China[4]Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, China[5]Department of Pathology, West China Hospital of Sichuan University, #37 Guoxue Street, Chengdu, Sichuan 610041, China四川大学华西医院[6]Department of Obstetric and Gynecologic, Henan Provincial People’s Hospital, Zhengzhou, Henan 450003, China[7]Department of Gynecological Oncology, Second People’s Hospital of Sichuan (Sichuan Cancer Hospital), Chengdu, Sichuan 610041, People’s Republic of China四川省肿瘤医院
Emerging evidence has indicated that apoptotic cells have a compensatory effect on the proliferation of neighboring cells. Recent studies have shown that apoptotic tumor cells stimulate the repopulation of tumors from a small number of surviving cells by cleaved caspase-3 regulation and elevated tumor cleaved (and thus activated) caspase-3 expression levels predict worse treatment outcomes in cancer patients. The prognostic significance of cleaved caspase-3 should be demonstrated in more human cancer types and larger subjects. Here, we examined the cleaved caspase-3 expression in 367 human tumor samples (gastric cancer: 97 cases, ovarian cancer: 65 cases, cervical cancer: 104 cases; colorectal cancer: 101 cases) with immunohistochemistry (IHC) and the relationship between the expression of cleaved caspase-3 and various clinicopathological factors were also detected. We found that, cleaved caspase-3 was significantly associated with pathological risk factors (P < 0.005) for the studied cancers, such as tumor stage, lymph-node metastasis, differentiation and so on. In univariate and multivariate analysis, patients with high expression of cleaved caspase-3 had a significant shorter overall survival time compared with those with low cleaved caspase-3 expression in gastric cancer (P < 0.001), ovarian cancer (P < 0.001), cervical cancer (P = 0.002), colorectal cancer (P < 0.001) individually and in the patients combined (P < 0.001). Cox regression results suggested cleaved caspase-3 as an independent prognosis predictor for the studied four cancer types. Our study showed cleaved caspase-3 was well correlated to progression, aggressive behaviors in the studied cancer, and implicated it as a potential predictive factor for the prognosis of the four cancer types. It also indicated cleaved caspase-3 as a potential therapeutic target for cancer patients.
基金：
Science Grant from Science and Technology Department of Sichuan Province, China (2012SZ0136) to Shanling Liu, also Supported by the Science Grant from National Natural Science Foundation of China (81270660) to He Wang, and the Young Scientific Innovation Team in Neurological Disorders grant 2011JTD0005 from the Department of Science and Technology of Sichuan Province, China.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[2]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[3]Department of Obstetric and Gynecologic, West China Second University Hospital, Sichuan University, Chengdu 610041, China[4]Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, China
通讯作者：
通讯机构：[1]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[2]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China[3]Department of Obstetric and Gynecologic, West China Second University Hospital, Sichuan University, Chengdu 610041, China[4]Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, China[*1]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan Unive-rsity, Chengdu 610041, China[*2]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan Univer-sity, Chengdu 610041, China
推荐引用方式(GB/T 7714)：
Qian Hu,Jing Peng,Weiping Liu,et al.Elevated cleaved caspase-3 is associated with shortened overall survival in several cancer types.[J].International journal of clinical and experimental pathology.2014,7(8):5057-70.
APA：
Qian Hu,Jing Peng,Weiping Liu,Xiaoli He,Ling Cui...&He Wang.(2014).Elevated cleaved caspase-3 is associated with shortened overall survival in several cancer types..International journal of clinical and experimental pathology,7,(8)
MLA：
Qian Hu,et al."Elevated cleaved caspase-3 is associated with shortened overall survival in several cancer types.".International journal of clinical and experimental pathology 7..8(2014):5057-70
