机构：[1]Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, CA 95817, USA.[2]Department of Internal Medicine, Division of Hematology/Oncology, University of California Davis, Sacramento, CA 95817, USA.[3]Department of Oncology, PLA Cancer Research Institute of the Second Affiliated Hospital, Third Military Medical University, Chongqing, 400037, China.[4]National Chengdu Center for Safety Evaluation of Drugs, West China Hospital, Sichuan University, Chengdu, 610041, China.四川大学华西医院[5]Beijing institute of technology, Beijing, 100081, China.[6]NSF Center for Biophotonics Science and Technology, University of California Davis, Sacramento, CA 95817, USA.[7]Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA 95817, USA.[8]UC Davis NMR Facility, Davis, CA 95616, USA.[9]Department of Biomedical Engineering, Center for Molecular and Genomic Imaging, University of California Davis, Davis, CA 95616, USA.[10]VA Northern California Health Care System, Mather, CA.
Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.
基金：
We thank Mr Joel Kugelmass and Dr Ruth Stephenson for the editorial help and the
financial support from NIH/NCI (3R01CA115483, to K.S.L.), NIH/NIBIB
(R01EB012569, to K.S.L.), DoD PRMRP Award (W81XWH-13-1-0490, to K.S.L.) and
Prostate Cancer Foundation Creative Award (to K.S.L.), NIH/NCI (1U43CA184113-01,
to Y.Li), DoD PCRP Award (W81XWH-12-1-0087, to Y.Li), VA Career Development
Award-2 (to C.P.) and the California Institute for Regenerative Medicine CIRM)
New Faculty Award (to C.P.).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
最新[2025]版：
大类|1 区综合性期刊
小类|1 区综合性期刊
第一作者：
第一作者机构：[1]Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, CA 95817, USA.
共同第一作者：
通讯作者：
通讯机构：[2]Department of Internal Medicine, Division of Hematology/Oncology, University of California Davis, Sacramento, CA 95817, USA.[10]VA Northern California Health Care System, Mather, CA.
推荐引用方式(GB/T 7714)：
Li Yuanpei,Lin Tzu-Yin,Luo Yan,et al.A smart and versatile theranostic nanomedicine platform based on nanoporphyrin.[J].Nature communications.2014,5:4712.doi:10.1038/ncomms5712.
APA：
Li Yuanpei,Lin Tzu-Yin,Luo Yan,Liu Qiangqiang,Xiao Wenwu...&Lam Kit S.(2014).A smart and versatile theranostic nanomedicine platform based on nanoporphyrin..Nature communications,5,
MLA：
Li Yuanpei,et al."A smart and versatile theranostic nanomedicine platform based on nanoporphyrin.".Nature communications 5.(2014):4712
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