Expression of activated signal transducer and activator of transcription-3 as a predictive and prognostic marker in advanced esophageal squamous cell carcinoma.
机构：[1]Department of Respiration, Affiliated Hospital of Hubei Institute for Nationalities, Enshi, Hubei Province, China[2]Department of Medical Oncology, Enshi Tujia and Miao Autonomous Prefecture Central Hospital, No. 158, Wu Yang Avenue, Enshi, Hubei Province, China[3]Department of Dermatology, Enshi Tujia and Miao Autonomous Prefecture Central Hospital, No. 158, Wu Yang Avenue, Enshi, Hubei Province, China[4]Department of Radiology, West China Hospital of Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, China.四川大学华西医院
Signal transducer and activator of transcription-3 (STAT3) is an oncogenic transcription factor constitutively active and aberrantly expressed in various types of malignancies, and the expression of p-STAT3 has been recognized as a predictor of poor survival. It remains unclear how variations in p-STAT3 expression influence clinical outcomes in esophageal squamous cell carcinoma (ESCC).
Between 1 January 2008 and 1 November 2013, 153 advanced esophageal squamous cell carcinoma patients (stage IV) from two cancer centers in West China were treated with paclitaxel and cisplatin. We retrospectively analyzed the clinical outcomes of patients with ESCC and examined the correlation between p-STAT3 levels and clinical outcomes in esophageal cancer patients.
Among the 153 patients, positive p-STAT3 expression was observed in 73 of 153 (47.7 %) cases. The median PFS for patients with positive expression of p-STAT3 and negative expression of p-STAT3 was 5.0 months and 6.9 months, respectively (P < 0.001). The median overall survival was significantly higher in patients with p-STAT3 negative tumors than in those with p-STAT3 positive tumors (9.9 vs 8.9 months, P = 0.026). Kaplan-Meier survival analysis showed that p-STAT3 expression was statistically indicative of a poor prognosis for progression-free survival.
These data showed that p-STAT3 expression was significantly associated with poor prognosis in patients with esophageal cancer and could be used as a predictive and prognostic marker in esophageal cancer.
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外文
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出版当年[2015]版：
大类|4 区医学
小类|4 区肿瘤学4 区外科
最新[2023]版：
大类|3 区医学
小类|3 区肿瘤学3 区外科
第一作者：
第一作者机构：[1]Department of Respiration, Affiliated Hospital of Hubei Institute for Nationalities, Enshi, Hubei Province, China[2]Department of Medical Oncology, Enshi Tujia and Miao Autonomous Prefecture Central Hospital, No. 158, Wu Yang Avenue, Enshi, Hubei Province, China
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推荐引用方式(GB/T 7714)：
Huang Chuying,Wang Li,Yang Xibiao,et al.Expression of activated signal transducer and activator of transcription-3 as a predictive and prognostic marker in advanced esophageal squamous cell carcinoma.[J].World journal of surgical oncology.2015,13:314.doi:10.1186/s12957-015-0726-z.
APA：
Huang Chuying,Wang Li,Yang Xibiao,Lai Lin,Chen Dian&Duan Chunyan.(2015).Expression of activated signal transducer and activator of transcription-3 as a predictive and prognostic marker in advanced esophageal squamous cell carcinoma..World journal of surgical oncology,13,
MLA：
Huang Chuying,et al."Expression of activated signal transducer and activator of transcription-3 as a predictive and prognostic marker in advanced esophageal squamous cell carcinoma.".World journal of surgical oncology 13.(2015):314
