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Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.

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机构: [1]Center for Research on Reproduction & Women’s Health [2]Abramson Family Cancer Research Institute [3]Department of Obstetrics and Gynecology [4]Department of Pharmacology [5]Department of Pathology and Laboratory Medicine [6]Department of Radiation Oncology [7]Department of Biostatistics and Epidemiology [8]Department of Medicine Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA [9]Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China [10]Department of Statistics, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA [11]Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan 250012, China [12]West China Medical School, Sichuan University, Chengdu 610041, China [13]Department of Surgical Sciences, Gynecologic Oncology, Azienda Ospedaliero - Universitaria Citta della Salute, Turin 10126, Italy [14]Wistar Institute, Philadelphia, PA 19104, USA [15]Ludwig Center for Cancer Research and Department of Oncology, University of Lausanne, Lausanne 1007, Switzerland [16]Cancer Genome Institute, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA [17]Department of Gynecologic Oncology [18]Center for RNA Interference and Non-Coding RNA [19]Department of Systems Biology University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
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The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein-coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments. Copyright © 2015 Elsevier Inc. All rights reserved.

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出版当年[2015]版:
大类 | 1 区 医学
小类 | 1 区 细胞生物学 1 区 肿瘤学
最新[2023]版:
大类 | 1 区 医学
小类 | 1 区 细胞生物学 1 区 肿瘤学
第一作者:
第一作者机构: [1]Center for Research on Reproduction & Women’s Health [9]Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
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通讯机构: [1]Center for Research on Reproduction & Women’s Health [2]Abramson Family Cancer Research Institute [3]Department of Obstetrics and Gynecology [8]Department of Medicine Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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