机构：[1]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second Hospital, Sichuan University, Chengdu 610041, China[2]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second Hospital, Sichuan University, Chengdu 610041, China[3]Department of Obstetric and Gynecologic, West China Second Hospital, Sichuan University, Chengdu 610041, China[4]Department of Pathology, West China Second Hospital, Sichuan University, Chengdu 610041, China
Histone H2AX phosphorylation is a sensitive marker for DSB which contributes to both genomic instability and cancer treatment. Monitoring its formation may be a sensitive means to monitor cancer progression and treatment effect.
To define the role of phospho-H2AX (pH2AX) expression in development and prognosis of epithelial ovarian cancer (EOC).
The expression of pH2AX in 87 EOC samples and 28 samples of normal ovarian tissues were examined by immunohistochemistry (IHC). The results were semi-quantitatively scored and analyzed by chi-square test. The overall survival time (OS) and disease free interval (DFI) were collected by follow-up and analyzed by Kaplan-Meier analysis.
The expression level of pH2AX protein in EOC were higher than that in normal tissues (P<0.001). Among the sensitive cases, high expression of pH2AX was found in 53.2% cases while for resistant cases, high expression rate was 80% (P=0.025). However, pH2AX expression was not significantly correlated with age, histopathological type, tumor differentiation, lymph node metastasis or FIGO stages. Kaplan-Meier analysis found that DFI was negatively correlated with the pH2AX expression, where higher expression of pH2AX resulted in shorter DFI while no OS difference was detected in our study.
pH2AX may be used to detect EOC at an early stage and identify women at higher risk for relapse.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
最新[2023]版：
无
第一作者：
第一作者机构：[3]Department of Obstetric and Gynecologic, West China Second Hospital, Sichuan University, Chengdu 610041, China
通讯作者：
通讯机构：[1]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second Hospital, Sichuan University, Chengdu 610041, China[2]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second Hospital, Sichuan University, Chengdu 610041, China[3]Department of Obstetric and Gynecologic, West China Second Hospital, Sichuan University, Chengdu 610041, China[*1]Laboratory of Genetics, West China Institute of Women and Children’s Health, West China Second Hospital, Sichuan University, Chengdu 610041, China.[*2]Laboratory of Cell and Gene Therapy, West China Institute of Women and Children’s Health, West China Second Hospital, Sichuan University, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Ling Mei,Qian Hu,Jing Peng,et al.Phospho-histone H2AX is a diagnostic and prognostic marker for epithelial ovarian cancer.[J].International journal of clinical and experimental pathology.2015,8(5):5597-602.
APA：
Ling Mei,Qian Hu,Jing Peng,Jiaying Ruan,Juan Zou...&He Wang.(2015).Phospho-histone H2AX is a diagnostic and prognostic marker for epithelial ovarian cancer..International journal of clinical and experimental pathology,8,(5)
MLA：
Ling Mei,et al."Phospho-histone H2AX is a diagnostic and prognostic marker for epithelial ovarian cancer.".International journal of clinical and experimental pathology 8..5(2015):5597-602
