机构：[1]Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.[2]College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China.[3]Department of Radiology, First Hospital of China Medical University, Shenyang 110001, China.
The combination of therapies and monitoring the treatment process has become a new concept in cancer therapy. Herein, gelatin-based microcapsules have been first reported to be used as microwave (MW) susceptible agent and magnetic resonance (MR) imaging contrast agent for cancer MW thermotherapy. Using the simple coacervation methods, ionic liquid (IL) and Fe3O4 nanoparticles (NPs) were wrapped in microcapsules, and these microcapsules showed good heating efficacy in vitro under MW irradiation. The results of cell tests indicated that gelatin/IL@Fe3O4 microcapsules possessed excellent compatibility in physiological environments, and they could effectively kill cancer cells with exposure to MW. The ICR mice bearing H22 tumors treated with gelatin/IL@Fe3O4 microcapsules were obtained an outstanding MW thermotherapy efficacy with 100% tumor elimination under ultralow density irradiation (1.8 W/cm(2), 450 MHz). In addition, the applicability of the microcapsules as an efficient contrast agent for MR imaging in vivo was evident. Therefore, these multifunctional microcapsules have a great potential for MR imaging-guided MW thermotherapy.
基金：
The authors acknowledge financial support from the National
Hi-Technology Research and Development Program (863
Program) (No. 2013AA032201 and 2012AA022701), the
National Natural Science Foundation of China (NSFC)
(61171049, 31400854 and 81201814)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|1 区工程技术
小类|2 区材料科学：综合3 区纳米科技
最新[2023]版：
大类|2 区材料科学
小类|2 区材料科学：综合2 区纳米科技
第一作者：
第一作者机构：[1]Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.[2]College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Du Qijun,Ma Tengchuang,Fu Changhui,et al.Encapsulating Ionic Liquid and Fe₃O₄ Nanoparticles in Gelatin Microcapsules as Microwave Susceptible Agent for MR Imaging-guided Tumor Thermotherapy.[J].ACS applied materials & interfaces.2015,7(24):13612-9.doi:10.1021/acsami.5b03230.
APA：
Du Qijun,Ma Tengchuang,Fu Changhui,Liu Tianlong,Huang Zhongbing...&Meng Xianwei.(2015).Encapsulating Ionic Liquid and Fe₃O₄ Nanoparticles in Gelatin Microcapsules as Microwave Susceptible Agent for MR Imaging-guided Tumor Thermotherapy..ACS applied materials & interfaces,7,(24)
MLA：
Du Qijun,et al."Encapsulating Ionic Liquid and Fe₃O₄ Nanoparticles in Gelatin Microcapsules as Microwave Susceptible Agent for MR Imaging-guided Tumor Thermotherapy.".ACS applied materials & interfaces 7..24(2015):13612-9
工程技术