机构：[1]The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine, Shanghai 200031, People’sRepublic of China[2]Department of Laboratory Medicine, National Key Laboratory of Biotherapy/CollaborativeInnovation Center of Biotherapy, and Cancer Center, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[3]CAS-MPG Partner Institute and Key Laboratory for Computational Biology, Shanghai Institutes for BiologicalSciences, Chinese Academy of Sciences, Yueyang Road 320, Shanghai 200031, People’s Republic of China[4]Infectious Diseases Department, Beijing You’an Hospital, Capital Medical University, Beijing 100069, People’sRepublic of China[5]Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, People’sRepublic of China[6]Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, People’sRepublic of China[7]Yili Prefecture Center for Disease Control and Prevention, Yining 835000, Xinjiang, People’sRepublic of China[8]Key Laboratory of AIDS Immunology of National Health and Family Planning Commission,Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang 110001,People’s Republic of China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,Hangzhou 310000, People’s Republic of China[9]Shanghai-MOST Laboratory of Disease and Health Genomics,Chinese National Human Genome Center at Shanghai, Shanghai 201203, People’s Republic of China
Genome-wide association studies (GWASs) have revealed several genetic loci associated with HIV-1 outcome following infection (e.g., HLA-C at 6p21.33) in multi-ethnic populations with genetic heterogeneity and racial/ethnic differences among Caucasians, African-Americans, and Hispanics. To systematically investigate the inherited predisposition to modulate HIV-1 infection in Chinese populations, we performed GWASs in three ethnically diverse HIV-infected patients groups (i.e., HAN, YUN, and XIN, N = 538). The reported loci at 6p21.33 was validated in HAN (e.g., rs9264942, P = 0.0018). An independent association signal (rs2442719, P = 7.85 × 10(-7), HAN group) in the same region was observed. Imputation results suggest that haplotype HLA-B*13:02/C*06:02, which can partially account for the GWAS signal, is associated with lower viral load in Han Chinese. Moreover, several novel loci were identified using GWAS approach including the top association signals at 6q13 (KCNQ5, rs947612, P = 2.15 × 10(-6)), 6p24.1 (PHACTR1, rs202072, P = 3.8 × 10(-6)), and 11q12.3 (SCGB1D4, rs11231017, P = 7.39 × 10(-7)) in HAN, YUN, and XIN groups, respectively. Our findings imply shared or specific mechanisms for host control of HIV-1 in ethnically diverse Chinese populations, which may shed new light on individualized HIV/AIDS therapy in China.
基金：
Mega-projects of National Science Research for the 12th Five-Year Plan [2012ZX10001-006]
第一作者机构：[1]The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine, Shanghai 200031, People’sRepublic of China
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通讯作者：
推荐引用方式(GB/T 7714)：
Wei Zejun,Liu Yang,Xu Heng,et al.Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations.[J].SCIENTIFIC REPORTS.2015,5:doi:10.1038/srep10879.
APA：
Wei Zejun,Liu Yang,Xu Heng,Tang Kun,Wu Hao...&Kong Xiangyin.(2015).Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations..SCIENTIFIC REPORTS,5,
MLA：
Wei Zejun,et al."Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations.".SCIENTIFIC REPORTS 5.(2015)
