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Efficacy of erlotinib in previously treated patients with advanced non-small cell lung cancer: analysis of the Chinese subpopulation in the TRUST study.

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收录情况： ◇ SCIE

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机构： [1]Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangdong Province. [2]Cancer Center of Sun Yat-Sen University, Guangdong Province. [3]Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing. [4]Hangzhou First People's Hospital, Zhejiang Province. [5]Lung Tumor Clinical Medicine Center, Shanghai Chest Hospital, Shanghai. [6]Department of Pulmonary Medicine, Zhongshan Hospital Affiliated with Fudan University, Shanghai. [7]Department of Medical Oncology, Tumor Hospital of Harbin Medical University, Helongjiang Province. [8]Tianjin Tumor Hospital, Tianjin. [9]Department of Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Sichuan Province. [10]Tongji Medical College, Huazhong University of Science and Technology, Hubei Province. [11]Nanjing Eight One Hospital, Jiangsu Province. [12]Beijing Lung Cancer Center, Capital Medical University, Beijing. [13]Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, PR China

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This study is to analyze the data of Chinese subpopulation in the Tarceva Lung Cancer Survival Treatment Study (TRUST-China) which was a global Phase IV study designed to provide erlotinib to previously treated patients with Stage IIIB/IV non-small cell lung cancer. Patients with pathologically confirmed, unresectable Stage IIIB/IV non-small cell lung cancer who were previously failed on or unsuitable for chemotherapy or radiotherapy were given erlotinib (150 mg/day, oral) until disease progression, intolerable toxicity or death. Efficacy and toxicity of the agent were evaluated. In total, 519 patients Chinese patients were analyzed. The TRUST-China had similar baseline characteristics to TRUST-Global except the greater percentage of adenocarcinoma and non-smoker cases. The response rate and disease control rate were 24.7 and 75.3%, respectively. Median progression-free survival and overall survival were 6.4 and 15.4 months in the general Chinese population in the TRUST, and 10.2 and 18.9 months in non-smokers with adenocarcinoma (n = 254). Median progression-free survival and overall survival were significantly longer in non-smokers with adenocarcinoma than those in other groups (P ≤ 0.0001 and P ≤ 0.0001, respectively). Eastern Cooperative Oncology Group Performance Status (≥ 2 vs. ≤ 1, hazard ratio = 1.746, P < 0.0001) and histology (squamous cell carcinoma vs. adenocarcinoma, hazard ratio = 1.595, P = 0.0008) were independent risk factors that affected survival according to Cox regression multivariate analysis. We confirmed the efficacy and safety of erlotinib in Chinese patients. Non-smoking patients with adenocarcinoma histology had the best clinical benefits. (NCT00949910). © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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出版当年[2015]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2015]版：

Q4 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 1.9 最新[2023版] 2.4 最新五年平均 1.889 出版当年[2015版] 2.01 出版当年五年平均 2.016 出版前一年[2014版] 1.905 出版后一年[2016版]

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第一作者机构： [1]Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangdong Province.

通讯作者：

通讯机构： [13]Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, PR China [*1]Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai 200433, PR China.

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