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SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling.

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机构： [1]Graduate School of Anhui Medical University, Hefei, PR China [2]Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850, PR China [3]Department of Hematology, General Hospital of Air Force, Beijing, PR China [4]Department of Hematology, PLA General Hospital, Beijing, PR China [5]Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China

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关键词： Senp1 Multiple myeloma IL-6 NF-кB

摘要：

SUMO/sentrin specific protease 1 (Senp1) is an important regulation protease in the protein sumoylation, which affects the cell cycle, proliferation and differentiation. The role of Senp1 mediated protein desumoylation in pathophysiological progression of multiple myeloma is unknown. In this study, we demonstrated that Senp1 is overexpressed and induced by IL-6 in multiple myeloma cells. Lentivirus-mediated Senp1 knockdown triggers apoptosis and reduces viability, proliferation and colony forming ability of MM cells. The NF-κB family members including P65 and inhibitor protein IkBα play important roles in regulation of MM cell survival and proliferation. We further demonstrated that Senp1 inhibition decreased IL-6-induced P65 and IkBα phosphorylation, leading to inactivation of NF-кB signaling in MM cells. These results delineate a key role for Senp1in IL-6 induced proliferation and survival of MM cells, suggesting it may be a potential new therapeutic target in MM. Copyright © 2015 Elsevier Inc. All rights reserved.

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出版当年[2015]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

第一作者：

第一作者机构： [1]Graduate School of Anhui Medical University, Hefei, PR China [2]Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850, PR China

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通讯作者：

通讯机构： [2]Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850, PR China [5]Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China [*1]Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, PR China.

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