机构：[1]Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 40038, China[2]Department of Thyroid Breast Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China[3]Institute of Hepatobiliary Pancreatic-Intestinal Diseases, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China[4]Department of Breast and Thyroid Surgery, Suining Central Hospital, Suining, Sichuan 629000, China[5]Department of Anatomy, The North Sichuan Medical College, Nanchong, Sichuan 637000, China[6]Department of Radiology, Wayne State University, Detroit, MI 48331, USA
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is often associated with biologic behavior with frequent distant metastasis. FAT tumor suppressor homolog 4 (FAT4), a cadherin-related protein, is involved in a variety of biological processes as a tumor suppressor; however, the role of FAT4 in TNBC is still unclear. The aim of our study was to identify the role of FAT4 in TNBC and examine the underlying molecular mechanisms. The expression of FAT4 was evaluated by immunohistochemistry, western blotting, and qRT-PCR in a series of TNBC tissues. The effects of FAT4 on the ability of cell proliferation, migration, and invasion were assessed by MTT assay and migration and invasion assays. We demonstrated that the repression of FAT4 by shRNA could promote TNBC progression. Taken together, our findings provide evidence for a role of the FAT4 cluster as a tumor suppressor in TNBC patients and may serve as potential novel targets for the treatment of TNBC.
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外文
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出版当年[2016]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 40038, China[2]Department of Thyroid Breast Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China[3]Institute of Hepatobiliary Pancreatic-Intestinal Diseases, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China
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推荐引用方式(GB/T 7714)：
Hou Lingmi,Chen Maoshan,Zhao Xiaobo,et al.FAT4 functions as a tumor suppressor in triple-negative breast cancer.[J].Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.2016,doi:10.1007/s13277-016-5421-3.
APA：
Hou Lingmi,Chen Maoshan,Zhao Xiaobo,Li Jingdong,Deng Shishan...&Jiang Jun.(2016).FAT4 functions as a tumor suppressor in triple-negative breast cancer..Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,,
MLA：
Hou Lingmi,et al."FAT4 functions as a tumor suppressor in triple-negative breast cancer.".Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine .(2016)
