机构：[1]Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.[2]Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, Sichuan 610041, China.[3]Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China.[4]Department of Thoracic Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China.
Previous studies have shown that some dysregulated miRNAs are involved in radioresistance of tumor cells. Here, we identified significantly decreased miR-424 expression in radioresistant cervical cancer cells and specimens from cervical cancer patients with radioresistance compared to their radiosensitive parental cells and specimens from radiosensitive patients, respectively. Ectopic expression of miR-424 significantly increased radiation-induced DNA damage, cell apoptosis and G2/M cell cycle arrest in radioresistant cervical cancer cells. Notably, miR-424 agomiR treatment can sensitize radioresistant cervical cancer cells to radiation in a xenograft model. Furthermore, we demonstrated that miR-424 regulated radiosensitivity by directly targeting aprataxin. Taken together, these findings suggest that miR-424 acts as a radiosensitizing miRNA and reveal a new therapeutic strategy for radioresistant cervical cancers.
基金：
the National Natural Science Foundations of China (No.81101993 and 81001000) and Startup Fund for Talented Scholars of Daping Hospital and Research Institute of Surgery, Third Military Medical University (to C.X.X and H.J).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|1 区医学
小类|2 区细胞生物学2 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.[2]Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, Sichuan 610041, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Xia,Li Qing,Jin Hua,et al.miR-424 acts as a tumor radiosensitizer by targeting aprataxin in cervical cancer.[J].Oncotarget.2016,7(47):77508-77515.doi:10.18632/oncotarget.12716.
APA：
Wang Xia,Li Qing,Jin Hua,Zou Hua,Xia Wei...&Qing Yi.(2016).miR-424 acts as a tumor radiosensitizer by targeting aprataxin in cervical cancer..Oncotarget,7,(47)
MLA：
Wang Xia,et al."miR-424 acts as a tumor radiosensitizer by targeting aprataxin in cervical cancer.".Oncotarget 7..47(2016):77508-77515
医学