机构：[1]Department of Thyroid Breast Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, P.R. China[2]Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China[3]Institute of Hepatobiliarypancreatic-Intestinal Diseases, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, P.R. China[4]Department of Breast and Thyroid Surgery, Suining Central Hospital, Suining, Sichuan, P.R. China[5]Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China[6]Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, P.R. China大连医科大学附属第一医院[7]Department of Anatomy, The North Sichuan Medical College, Nanchong, Sichuan, P.R. China[8]Department of Radiology, Wayne State University, Detroit, MI, U.S.A.
BACKGROUND Breast cancer is the main type of cancer in women, and triple-negative breast cancer (TNBC) is a unique subtype of breast cancer. The expression of miR-940 has been shown to play an important role in various cancers; however, the role of miR-940 in TNBC remains unknown. MATERIAL AND METHODS The expression of miR-940 in TNBC tissues or cells were tested by qRT-PCR; the expression of miR-940 in cells were overexpressed by miR-940 mimics, and suppressed by anti-miR-940. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-940. The interaction between miR-940 and ZNF24 was confirmed by dual luciferase assays. The protein level was assayed by Western blot. RESULTS TNBC tissues and cells showed lower miR-940 levels. CONCLUSIONS MiR-940 inhibited cellular proliferation and migration in TNBC.
基金：
This work was supported by grants from the National Natural Science Foundation of China (Grants No. 81172496), grants from The North Sichuan Medical College (Grants No. CBY12-A-QN07), grants from Education Department of Sichuan Province (Grants No.13ZA0228) and grants from Science and Technology Department of Sichuan Province (Grants No.2016060)
第一作者机构：[1]Department of Thyroid Breast Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, P.R. China[2]Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China[3]Institute of Hepatobiliarypancreatic-Intestinal Diseases, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, P.R. China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Lingmi Hou,Maoshan Chen,Hongwei Yang,et al.MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer.[J].MEDICAL SCIENCE MONITOR.2016,22:3666-3672.doi:10.12659/msm.897731.
APA：
Lingmi Hou,Maoshan Chen,Hongwei Yang,Tianyong Xing,Jingdong Li...&Jun Jiang.(2016).MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer..MEDICAL SCIENCE MONITOR,22,
MLA：
Lingmi Hou,et al."MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer.".MEDICAL SCIENCE MONITOR 22.(2016):3666-3672
