机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, No.17, 3rd Section of People’s South Road, Chengdu 610041, Republic of China四川大学华西医院[2]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, Republic of China四川大学华西医院[3]Laboratory of Cell andMolecular Biology&State Key Laboratory of Molecular Oncology, Cancer Institute & Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100034, People’s Republic of China
The protein ARHGDIA has been found to play distinct roles in cancer progression for several tumors. However, it remains elusive whether and how ARHGDIA plays functions in human glioma. In this study, we discovered that ARHGDIA is much downregulated in human glioma; meanwhile, its expression negatively correlates with glioma malignancy and positively relates to prognosis of glioma patients. It has independent predictive value of ARHGDIA expression level for overall survival of human glioma patients. Glioma patients with ARHGDIA-positive expression have a longer overall survival time than ARHGDIA-negative patients. Knockdown of ARHGDIA promotes cell proliferation, cell cycle progression, and cell migration due to the activation of Rho GTPases (Rac1, Cdc42, and RhoA) and Akt phosphorylation, whereas overexpression of ARHGDIA suppresses cell growth, cell cycle progression, and cell migration. ARHGDIA is a potential prognostic marker and therapeutic target for human glioma.
基金：
National Key Basic Research Program of China (2013CB911303,
2011CB910703), National 863 High Tech Foundation (2014AA020608),
National Natural Sciences Foundation of China (31470810, 31071235,
30970654), and the Doctoral Program of Higher Education
(20120181110025).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, No.17, 3rd Section of People’s South Road, Chengdu 610041, Republic of China
通讯作者：
推荐引用方式(GB/T 7714)：
Lu Weiliang,Wang Xixi,Liu Jingjing,et al.Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway.[J].Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.2016,doi:10.1007/s13277-016-5374-6.
APA：
Lu Weiliang,Wang Xixi,Liu Jingjing,He Yu,Liang Ziwei...&Liang Shufang.(2016).Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway..Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,,
MLA：
Lu Weiliang,et al."Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway.".Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine .(2016)
