机构:[1]Department of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China四川大学华西医院[2]GCP Center/Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China四川大学华西医院
No pharmacokinetic data of intravenous ibuprofen were available in a Chinese population and the published information remained inadequate. The present study aimed to investigate the pharmacokinetic properties of intravenous ibuprofen in healthy Chinese volunteers after single- and multiple-dose administration.
Twelve subjects received single doses of 200, 400, and 800 mg intravenous ibuprofen, respectively, and multiple doses of 400 mg intravenous ibuprofen, four times per day (every 6 h) till the morning of the sixth day in each study period.
After single doses of 200, 400 and 800 mg and multiple doses of 400 mg intravenous ibuprofen, the main pharmacokinetic parameters obtained were: maximum plasma concentration (C max) 23.05 ± 2.96, 41.90 ± 3.22, 76.06 ± 8.70, and 49.53 ± 3.92 μg/ml, respectively, which were achieved immediately at the end of the infusion; area under the plasma concentration-time curve from time zero to the time of last quantifiable concentration (AUC0-t ) 49.82 ± 10.92, 88.79 ± 12.43, 152.34 ± 25.23, and 106.68 ± 18.94 µg·h/mL, respectively; AUC from time zero to infinity (AUC0-∞) 51.91 ± 10.67, 91.46 ± 12.06, 155.04 ± 25.70, and 108.58 ± 19.49 µg·h/ml, respectively; half-life (t ½) 1.87 ± 0.30, 1.93 ± 0.24, 2.02 ± 0.38, and 1.74 ± 0.26 h, respectively. The accumulation index (AI) was 1.22 ± 0.17 after multiple doses. The most obvious accumulation was observed in males; other parameters revealed no significant differences.
Similar pharmacokinetic properties of intravenous ibuprofen in healthy Chinese volunteers were observed to those reported in a Caucasian population. Multiple doses of intravenous ibuprofen every 6 h caused slight accumulation. Except for the AI, sex did not affect the pharmacokinetics of intravenous ibuprofen. CHICTR.
ChiCTR-IIR-15007347.
基金:
The study was sponsored and funded by Beijing Alica
Pharmaceutical Sci-Tech Co. Ltd. (Beijing, People’s Republic of
China).
语种:
外文
PubmedID:
中科院(CAS)分区:
出版当年[2016]版:
大类|4 区医学
小类|4 区药学
最新[2023]版:
大类|3 区医学
小类|3 区药学
第一作者:
第一作者机构:[1]Department of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China
通讯作者:
推荐引用方式(GB/T 7714):
Shen Yali,Nan Feng,Li Mei,et al.Pharmacokinetic Properties of Intravenous Ibuprofen in Healthy Chinese Volunteers.[J].Clinical drug investigation.2016,36(12):1051-1058.doi:10.1007/s40261-016-0453-4.
APA:
Shen Yali,Nan Feng,Li Mei,Liang Maozhi,Wang Ying...&Luo Zhu.(2016).Pharmacokinetic Properties of Intravenous Ibuprofen in Healthy Chinese Volunteers..Clinical drug investigation,36,(12)
MLA:
Shen Yali,et al."Pharmacokinetic Properties of Intravenous Ibuprofen in Healthy Chinese Volunteers.".Clinical drug investigation 36..12(2016):1051-1058