机构：[1]Department of Radiology, the First Hospital of China Medical University, No. 155 Nanjing North Road, Shenyang 110001, People’s Republic of China[2]Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China[3]College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China
Herein, we develop a novel integrated strategy for the preparation of theranostic chitosan microcapsules by encapsulating ion liquids (ILs) and Fe3O4 nanoparticles. The as-prepared chitosan/Fe3O4@IL microcapsules exhibit not only significant heating efficacy in vitro under microwave (MW) irradiation but also obvious enhancement of T2-weighted magnetic resonance (MR) imaging, besides the excellent biocompatibility in physiological environments. The chitosan/Fe3O4@IL microcapsules show ideal temperature rise and therapeutic efficiency when applied to microwave thermal therapy in vivo. Complete tumor elimination is realizing after MW irradiation at an ultralow power density (1.8 W/cm(2)), while neither the MW group nor the chitosan microcapsule group has significant influence on the tumor development. The applicability of the chitosan/Fe3O4@IL microcapsules as an efficient contrast agent for MR imaging is proved in vivo. Moreover, the result of in vivo systematic toxicity shows that chitosan/Fe3O4@IL microcapsules have no acute fatal toxicity. Our study presents an interesting type of multifunctional platform developed by chitosan microcapsule promising for imaging-guided MW thermotherapy.
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外文
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中科院(CAS)分区：
出版当年[2016]版：
大类|2 区工程技术
小类|3 区材料科学：综合3 区物理：应用4 区纳米科技
最新[2023]版：
大类|3 区材料科学
小类|3 区材料科学：综合3 区物理：应用4 区纳米科技
第一作者：
第一作者机构：[1]Department of Radiology, the First Hospital of China Medical University, No. 155 Nanjing North Road, Shenyang 110001, People’s Republic of China[2]Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China[3]College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China
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推荐引用方式(GB/T 7714)：
Tang Shunsong,Du Qijun,Liu Tianlong,et al.In Vivo Magnetic Resonance Imaging and Microwave Thermotherapy of Cancer Using Novel Chitosan Microcapsules.[J].Nanoscale research letters.2016,11(1):334.doi:10.1186/s11671-016-1536-0.
APA：
Tang Shunsong,Du Qijun,Liu Tianlong,Tan Longfei,Niu Meng...&Shao Haibo.(2016).In Vivo Magnetic Resonance Imaging and Microwave Thermotherapy of Cancer Using Novel Chitosan Microcapsules..Nanoscale research letters,11,(1)
MLA：
Tang Shunsong,et al."In Vivo Magnetic Resonance Imaging and Microwave Thermotherapy of Cancer Using Novel Chitosan Microcapsules.".Nanoscale research letters 11..1(2016):334
