机构：[1]Department of Stomatology, Taihe Hospital, Institute of Oral andMaxillofacial Surgery, Hubei University of Medicine, Shiyan 442000, China[2]Department of Stomatology, Daping Hospital & Research Institute ofSurgery, Third Military Medical University, Chongqing 400042, China[3]Chinese Cochrane Center, Chinese Evidence-Based Medicine Center,Western China Hospital, West China Hospital, Sichuan University, Chengdu610041, China四川大学华西医院[4]Department of Stomatology, Zhuhai People’s Hospital,Zhuhai Hospital Affiliated with Jinan University, Zhuhai 519000, China[5]Department of Stomatology, Center for Evidence-Based and TranslationalMedicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road,Wuhan 430071, China武汉大学口腔医院
Numerous case-control studies have been performed to investigate the association between three cyclooxygenase-2 (COX-2) polymorphisms (rs20417 (-765G > C), rs689466 (-1195G > A), and rs5275 (8473 T > C)) and the risk of head and neck squamous cell carcinoma (HNSCC). However, the results were inconsistent. Therefore, we conducted this meta-analysis to investigate the association.
We searched in PubMed, Embase, and Web of Science up to January 20, 2015 (last updated on May 12, 2016). Two independent reviewers extracted the data. Odds ratios (ORs) with their 95 % confidence intervals (CIs) were used to assess the association. All statistical analyses were performed using the Review Manager (RevMan) 5.2 software.
Finally 8 case-control studies were included in this meta-analysis. For unadjusted data, an association with increased risk was observed in three genetic models in COX-2 rs689466 polymorphism; however, COX-2 rs5275 and rs20417 polymorphisms were not related to HNSCC risk in this study. The pooled results from adjusted data all revealed non-significant association between these three polymorphisms and risk of HNSCC. We also found a similar result in the subgroup analyses, based on both unadjusted data and adjusted data.
Current results suggest that COX-2 rs689466, rs5275, and rs20417 polymorphisms are not associated with HNSCC. Further large and well-designed studies are necessary to validate this association.
基金：
This research was supported (in part) by the Nature Science Foundation of
Hubei Province (2012FFB03902) and the Foundation of Evidence-based
Medicine Nursery Fund of Taihe Hospital (EBM2013002 and EBM20140067),
without commercial or not-for-profit sectors.
第一作者机构：[1]Department of Stomatology, Taihe Hospital, Institute of Oral andMaxillofacial Surgery, Hubei University of Medicine, Shiyan 442000, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Stomatology, Taihe Hospital, Institute of Oral andMaxillofacial Surgery, Hubei University of Medicine, Shiyan 442000, China[5]Department of Stomatology, Center for Evidence-Based and TranslationalMedicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road,Wuhan 430071, China
推荐引用方式(GB/T 7714)：
Leng Wei-Dong,Wen Xiu-Jie,Kwong Joey S W,et al.COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data.[J].BMC CANCER.2016,16:-.doi:10.1186/s12885-016-2535-3.
APA：
Leng Wei-Dong,Wen Xiu-Jie,Kwong Joey S W,Huang Wei,Chen Jian-Gang&Zeng Xian-Tao.(2016).COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data..BMC CANCER,16,
MLA：
Leng Wei-Dong,et al."COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data.".BMC CANCER 16.(2016):-
医学