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MiR-486-3p targeting ECM1 represses cell proliferation and metastasis in cervical cancer.

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机构： [1]Department of Obstetrics and Gynecology, The Affiliated Hospital of SouthWest Medical University, Sichuan, China [2]Department of Obstetrics and Gynecology, The Affiliated TCM Hospital of SouthWest Medical University, Sichuan, China [3]The Institute of Cancer Research, SouthWest Medical University, Sichuan, China [4]Experimental Medicine Center, The Affiliated Hospital of SouthWest Medical University, Sichuan, China

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MicroRNAs (miRNAs) regulate gene expression and are involved in cervical cancer. But the molecular mechanism is still unclear. Here, miRNA profile of cervical cancer was performed and demonstrated that miR-486-3p decreased in specimens of cervical cancer patients. In addition, our clinical data show that decreased miR-486-3p was associated with metastasis in cervical cancer patients. ECM1 was predicted and velified as a target gene of miR-486-3p. Overexpression of miR-486-3p inhibited cell growth and metastasis by targeting ECM1. In a conclusion, these findings suggest that miR-486-3p is a tumor suppressor miRNA and induction of miR-486-3p is a potential strategy to inhibit cervical cancer progression. Copyright © 2016. Published by Elsevier Masson SAS.

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出版当年[2016]版：

大类 | 3 区医学

小类 | 4 区医学：研究与实验 4 区药学

最新[2023]版：

大类 | 2 区

医学

小类 | 1 区药学 2 区医学：研究与实验

第一作者：

第一作者机构： [1]Department of Obstetrics and Gynecology, The Affiliated Hospital of SouthWest Medical University, Sichuan, China

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通讯机构： [4]Experimental Medicine Center, The Affiliated Hospital of SouthWest Medical University, Sichuan, China [*1]Experimental Medicine Center, The Affiliated Hospital of SouthWest Medical University, 25 Taiping Road, Lu Zhou, Sichuan 646000, China

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