机构：[1]Department of Cell Biology, University of Pittsburgh School of Medicineand University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117Centre Avenue, HCC2.6c, Pittsburgh, PA 15213, USA[2]State Key Laboratoryof Oral Diseases, West China Hospital of Stomatology, Sichuan University,Chengdu 610041, Sichuan, Peoples’ Republic of China.
PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of signaling proteins, facilitating the initiation, amplification and transduction of signaling. Accumulating evidence suggest that several key signaling molecules in Hippo signaling pathway are tightly regulated by various types of PTMs. Malfunction of these critical signaling modules such as YAP/TAZ, MAT1/2 and LATS1/2 due to deregulated PTMs has been linked to a variety of human diseases such as cancer. In this review article, we summarized the current understanding of the impact of PTMs in regulating Hippo signaling pathway and further discussed the potential therapeutic intervention from the view of PTMs and Hippo pathway.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区生物
小类|4 区细胞生物学
最新[2023]版：
大类|4 区生物学
小类|4 区细胞生物学
第一作者：
第一作者机构：[1]Department of Cell Biology, University of Pittsburgh School of Medicineand University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117Centre Avenue, HCC2.6c, Pittsburgh, PA 15213, USA[2]State Key Laboratoryof Oral Diseases, West China Hospital of Stomatology, Sichuan University,Chengdu 610041, Sichuan, Peoples’ Republic of China.
通讯作者：
推荐引用方式(GB/T 7714)：
He Mingjing,Zhou Zhuan,Shah Anil A,et al.New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics.[J].Cell division.2016,11:4.doi:10.1186/s13008-016-0013-6.
APA：
He Mingjing,Zhou Zhuan,Shah Anil A,Hong Yang,Chen Qianming&Wan Yong.(2016).New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics..Cell division,11,
MLA：
He Mingjing,et al."New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics.".Cell division 11.(2016):4
