Modification of association between prior lung disease and lung cancer by inhaled arsenic: A prospective occupational-based cohort study in Yunnan, China.
机构：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, PR China.[2]Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 10021, PR China.[3]Divisions of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland, USA.[4]Third People's Hospital of Honghe Autonomous District, Yunnan, PR China.[5]Kunming Medical University, Yunnan, PR China.[6]Lung cancer Center, West China Hospital, Sichuan University, Chengdu, PR China.四川大学华西医院
Arsenic and prior lung diseases have been shown to increase lung cancer risk; however, little is known about their joint effects. The aim of our study was to analyze the joint effects of inhaled arsenic and prior lung diseases on lung cancer risk within a occupational cohort. The interactions of prior lung diseases and inhaled arsenic were analyzed based on multiplicative and additive scales in the Cox proportional hazards model. Compared with low arsenic exposure and no history of asthma, the hazard ratios (HRs) of high arsenic exposure with asthma, high arsenic exposure without asthma and low arsenic exposure with asthma were 2.61 (95% CI: 1.71-4.00), 2.60 (95% CI: 1.93-3.51) and 2.49 (95% CI: 1.53-4.06), respectively. Based on the multiplicative scale in the Cox proportional hazards model, the HR of the interaction of asthma and arsenic on lung cancer risk was 0.45 (95% CI: 0.25-0.80). Based on the additive scale, the relative excess risk due to interaction between asthma and arsenic was -1.41 (95% CI: -2.81 to -0.02). Our study provides strong evidence that arsenic exposure is associated with lung cancer risk. A significant negative interaction between asthma and arsenic on lung cancer risk is observed.
基金：
This study was supported by the National Cancer Institute/National Institute of
Health, contract no. 263-MQ-511694.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区医学
小类|2 区环境科学2 区公共卫生、环境卫生与职业卫生2 区毒理学
最新[2023]版：
大类|3 区医学
小类|2 区毒理学3 区环境科学3 区公共卫生、环境卫生与职业卫生
第一作者：
第一作者机构：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, PR China.
通讯作者：
通讯机构：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, PR China.[2]Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 10021, PR China.[6]Lung cancer Center, West China Hospital, Sichuan University, Chengdu, PR China.[*1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, 154 Anshan Street, Tianjin 300052, PR China[*2]Sichuan Lung Cancer Institute/Center, West China Hospital, Sichuan University, 37 Guo Xue Lane, Wuhou District, Chengdu, Sichuan 610041, PR China[*3]Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 South, Panjiayuan Lane, Beijing 10021, PR China
推荐引用方式(GB/T 7714)：
Fan Yaguang,Jiang Yong,Hu Ping,et al.Modification of association between prior lung disease and lung cancer by inhaled arsenic: A prospective occupational-based cohort study in Yunnan, China.[J].Journal of exposure science & environmental epidemiology.2016,26(5):464-70.doi:10.1038/jes.2016.22.
APA：
Fan Yaguang,Jiang Yong,Hu Ping,Chang Runsheng,Yao Shuxiang...&Qiao Youlin.(2016).Modification of association between prior lung disease and lung cancer by inhaled arsenic: A prospective occupational-based cohort study in Yunnan, China..Journal of exposure science & environmental epidemiology,26,(5)
MLA：
Fan Yaguang,et al."Modification of association between prior lung disease and lung cancer by inhaled arsenic: A prospective occupational-based cohort study in Yunnan, China.".Journal of exposure science & environmental epidemiology 26..5(2016):464-70
