机构：[1]Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China[2]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.[3]Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637007, China[4]The State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
Gliomas are the most common primary brain tumors and have a very dismal prognosis. However, recent advancements in nanomedicine and nanotechnology provide opportunities for personalized treatment regimens to improve the poor prognosis of patients suffering from glioma. This comprehensive review starts with an outline of the current status facing glioma. It then provides an overview of the state-of-the-art applications of iron oxide nanoparticles (IONPs) to glioma diagnostics and therapeutics, including MR contrast enhancement, drug delivery, cell labeling and tracking, magnetic hyperthermia treatment and magnetic particle imaging. It also addresses current challenges associated with the biological barriers and IONP design with an emphasis on recent advances and innovative approaches for glioma targeting strategies. Opportunities for future development are highlighted.
基金：
This work was supported by NSFC under Grant no. 81271626,
81571660, 81422023, and 51273165, MOST of China (2014CB744503 and 2013CB733802), Program for New Century
Excellent Talents in University (NCET-13-0502), Fundamental
Research Funds for the Central Universities (2013121039) and
Chongqing Science and Technology R&D Base Construction
(International Cooperation) Project (cstc2014gjhz110002).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|1 区工程技术
小类|2 区化学综合2 区材料科学：综合2 区纳米科技2 区物理：应用
最新[2023]版：
大类|3 区材料科学
小类|3 区化学：综合3 区材料科学：综合3 区纳米科技3 区物理：应用
第一作者：
第一作者机构：[1]Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China[2]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
通讯作者：
通讯机构：[1]Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China[4]The State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
推荐引用方式(GB/T 7714)：
Liu Heng,Zhang Jun,Chen Xiao,et al.Application of iron oxide nanoparticles in glioma imaging and therapy: from bench to bedside.[J].Nanoscale.2016,8(15):7808-26.doi:10.1039/c6nr00147e.
APA：
Liu Heng,Zhang Jun,Chen Xiao,Du Xue-Song,Zhang Jin-Long...&Zhang Wei-Guo.(2016).Application of iron oxide nanoparticles in glioma imaging and therapy: from bench to bedside..Nanoscale,8,(15)
MLA：
Liu Heng,et al."Application of iron oxide nanoparticles in glioma imaging and therapy: from bench to bedside.".Nanoscale 8..15(2016):7808-26
工程技术