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Overexpression of miR-96 promotes cell proliferation by targeting FOXF2 in prostate cancer.

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资源类型：
Pubmed体系：
作者：
Wu-Ran Wei[1] ; Guo-Jun Zeng[2] ; Chang Liu[3] ; Bing-Wen Zou[4] ; Li Li[5,6,*1] ;
机构： [1]Institute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, China [2]Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu, China [3]Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China [4]Department of Oncology, West China Hospital, Sichuan University, Chengdu, China [5]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China [6]Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
出处：

关键词： Prostate cancer miR-96 FOXF2 cell proliferation

摘要：
Prostate cancer (PC) is one of the most common cancers in males. MicroRNAs (miRNAs) are demonstrated to be involved in prostate cancer development and progression. Recently, miR-96 was identified to play a tumor promoting role in several tumors including PC, however, the underlying function of miR-96 in PC still need to be known. In the study, our results demonstrated that miR-96 was higher in prostate cancer tissues compared with adjacent normal tissues. Higher miR-96 was association with higher PSA level, lymph node metastasis, pathologic stage and distant metastasis in prostate cancer patients. Lose-of-function studies showed that down-regulated expression of miR-96 inhibited cell proliferation and cell cycle by regulating down-regulating CyclinA1, CDK2 and CDK4 expression in PC cells. Furthermore, we found that FOXF2 was a target of miR-96 in PC cells and miR-96 promoted cell proliferation by suppressing FOXF2 expression. Thus, these results showed that inhibition of miR-96 may be a target for prostate cancer treatment. IJCEP Copyright © 2017.

基金：
National Natural Science Foundation of China (No. 81370272, 30901621/C1705).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 病理学
最新[2023]版：
无
第一作者：
第一作者机构： [1]Institute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, China
通讯作者：
通讯机构： [5]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China [6]Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China [*1]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) and Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, Section 3, Renmin South Road, Chengdu, Sichuan, China
推荐引用方式(GB/T 7714)：
Wu-Ran Wei,Guo-Jun Zeng,Chang Liu,et al.Overexpression of miR-96 promotes cell proliferation by targeting FOXF2 in prostate cancer.[J].International journal of clinical and experimental pathology.2017,10(7):7596-7602.
APA：
Wu-Ran Wei,Guo-Jun Zeng,Chang Liu,Bing-Wen Zou&Li Li.(2017).Overexpression of miR-96 promotes cell proliferation by targeting FOXF2 in prostate cancer..International journal of clinical and experimental pathology,10,(7)
MLA：
Wu-Ran Wei,et al."Overexpression of miR-96 promotes cell proliferation by targeting FOXF2 in prostate cancer.".International journal of clinical and experimental pathology 10..7(2017):7596-7602

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