机构：[1]State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu 610041, P. R. China.四川大学华西医院[2]National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University , Shenzhen 518060, Guangdong P. R. China.深圳市康宁医院深圳医学信息中心[3]Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Wuhan Institute of Technology , Wuhan 430073, China.
A facile and general coordination-precipitation method is developed to synthesize insoluble metal Roussin's black salts (Me-RBSs) as a new type of NIR-responsive NORMs. The weak-field ligand coordination of metal+-RBS- brings a NIR absorption effect of Me-RBSs, and further gives rise to the NIR adsorption-dependent NIR-responsive NO release profile. Intratumoral NIR-responsive release of NO effectively inhibits the growth and metastasis of the metastatic breast cancer. Aqueous insolubility of Me-RBSs ensures lower cytotoxicity and higher thermostability compared with traditional soluble RBSs. This work establishes a new class of NIR-sensitive NO donors, and may spark new inspiration for designing intelligent gas-releasing molecules.
基金：
National Natural Science Foundation of China
(Grants 31525009, 81601605, 81501572, 51402220), Sichuan
Innovative Research Team Program for Young Scientists
(2016TD0004), Shenzhen Basic Research Program
(JCYJ20170302151858466), Natural Science Foundation of
SZU ( 82 7 - 0 0 0 1 4 3 ) , Shenzhen Pe a c o c k P l a n
(KQTD2016053112051497), the Fundamental Research
Funds for the Shenzhen University, China (2016076), State
Key Laboratory of Advanced Technology for Materials
Synthesis and Processing, and Wuhan University of Technology
(2017-KF-6).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|1 区工程技术
小类|2 区材料科学：综合2 区纳米科技
最新[2023]版：
大类|2 区材料科学
小类|2 区材料科学：综合2 区纳米科技
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu 610041, P. R. China.
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Lijuan,He Qianjun,Lei Minyi,et al.Facile Coordination-Precipitation Route to Insoluble Metal Roussin's Black Salts for NIR-Responsive Release of NO for Anti-Metastasis.[J].ACS applied materials & interfaces.2017,9(42):36473-36477.doi:10.1021/acsami.7b11325.
APA：
Chen Lijuan,He Qianjun,Lei Minyi,Xiong Liwei,Shi Kun...&Qian Zhiyong.(2017).Facile Coordination-Precipitation Route to Insoluble Metal Roussin's Black Salts for NIR-Responsive Release of NO for Anti-Metastasis..ACS applied materials & interfaces,9,(42)
MLA：
Chen Lijuan,et al."Facile Coordination-Precipitation Route to Insoluble Metal Roussin's Black Salts for NIR-Responsive Release of NO for Anti-Metastasis.".ACS applied materials & interfaces 9..42(2017):36473-36477
工程技术