机构：[1]Center for Pharmacogenomics, School of Pharmacy, and State Key Laboratory of Genetic Engineering, Schoolof Life Sciences and Shanghai Cancer Hospital/Cancer Institute, Fudan University, Shanghai, 200438, China[2]Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, 200438, China[3]College of Chemistry, Sichuan University, Chengdu, 610064, China[4]Mutagenesis and Genomics Team, RIKENBioResource Center, Tsukuba, Ibaraki, 305-0074, Japan
The mouse has been widely used as a model organism for studying human diseases and for evaluating drug safety and efficacy. Many diseases and drug effects exhibit tissue specificity that may be reflected by tissue-specific gene-expression profiles. Here we construct a comprehensive mouse transcriptomic BodyMap across 17 tissues of six-weeks old C57BL/6JJcl mice using RNA-seq. We find different expression patterns between protein-coding and non-coding genes. Liver expressed the least complex transcriptomes, that is, the smallest number of genes detected in liver across all 17 tissues, whereas testis and ovary harbor more complex transcriptomes than other tissues. We report a comprehensive list of tissue-specific genes across 17 tissues, along with a list of 4,781 housekeeping genes in mouse. In addition, we propose a list of 27 consistently and highly expressed genes that can be used as reference controls in expression-profiling analysis. Our study provides a unique resource of mouse gene-expression profiles, which is helpful for further biomedical research.
基金：
This work was
supported in part by the National Natural Science Foundation of China (31471239, 31671368, and 31601085),
The National Key Research and Development Program of China (2016YFC0901704), the 111 Project (B13016)
and JSPS KAKENHI (25241016).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
最新[2023]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
第一作者：
第一作者机构：[1]Center for Pharmacogenomics, School of Pharmacy, and State Key Laboratory of Genetic Engineering, Schoolof Life Sciences and Shanghai Cancer Hospital/Cancer Institute, Fudan University, Shanghai, 200438, China[2]Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, 200438, China
共同第一作者：
通讯作者：
通讯机构：[1]Center for Pharmacogenomics, School of Pharmacy, and State Key Laboratory of Genetic Engineering, Schoolof Life Sciences and Shanghai Cancer Hospital/Cancer Institute, Fudan University, Shanghai, 200438, China[2]Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, 200438, China
推荐引用方式(GB/T 7714)：
Bin Li,Tao Qing,Jinhang Zhu,et al.A Comprehensive Mouse Transcriptomic BodyMap across 17 Tissues by RNA-seq.[J].Scientific reports.2017,7(1):4200.doi:10.1038/s41598-017-04520-z.
APA：
Bin Li,Tao Qing,Jinhang Zhu,Zhuo Wen,Ying Yu...&Leming Shi.(2017).A Comprehensive Mouse Transcriptomic BodyMap across 17 Tissues by RNA-seq..Scientific reports,7,(1)
MLA：
Bin Li,et al."A Comprehensive Mouse Transcriptomic BodyMap across 17 Tissues by RNA-seq.".Scientific reports 7..1(2017):4200
