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Tumor grade related expression of neuroglobin is negatively regulated by PPARγ and confers antioxidant activity in glioma progression.

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机构： [a]Laboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China [b]Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China [c]Department of Neurology, Shuangnan hospital of Chengdu, Chengdu 610000, China [d]Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, West China hospital, Sichuan University, Chengdu 610041, China [e]Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China

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Neuroglobin (NGB), distributed mainly in central and peripheral nervous systems, is a nerve globin with neuroprotective effects against oxidative stress resulting from hypoxia and ischemia. Recent studies have indicated that the expression of NGB is related to neurodegenerative disorders and cancers, but the molecular mechanisms for its transcriptional regulation and protection are not well defined. Here, we report that the expression of NGB in glioma is grade related and is negatively regulated by PPARγ. Specific PPARγ agonist reduces the expression of NGB, while its inhibitor enhances the expression. Moreover, NGB participates in regulating the phosphorylation of AKT in glioma cells, which may contribute to the glioma progression where accumulating oxidative pressure presents. Overexpression of NGB could protect glioma cells against 4-HNE induced cell death, and partially reverse PPARγ's pro-apoptotic and anti-proliferative abilities. These results display an important role of NGB in glioma progression and a mechanism for its transcriptional regulation, and suggest that the treatment on glioma through PPARγ agonist appears to be triggered by the modulation of NGB. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

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出版当年[2017]版：

大类 | 2 区生物

小类 | 2 区生化与分子生物学

最新[2025]版：

大类 | 1 区

生物学

小类 | 1 区生化与分子生物学

第一作者：

第一作者机构： [a]Laboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China [c]Department of Neurology, Shuangnan hospital of Chengdu, Chengdu 610000, China

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通讯作者：

通讯机构： [a]Laboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China [b]Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China [*1]Laboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.

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