机构：[1]Fachbereich Physik,Philipps Universitat Marburg, 35037 Marburg, Germany[2]Fachbereich Medizin,Philipps Universitat Marburg, 35037 Marburg, Germany[3]Fachbereich Pharmazie,Philipps Universitat Marburg, 35037 Marburg, Germany[4]Department of Chemistry, Philipps Universitat Marburg, 35037 Marburg, Germany[5]ENT-Department, Section of Experimental Oncology & Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship for Nanomedicine, University Hospital Erlangen, 91054 Erlangen, Germany[6]Department of Physical Chemistry, Universitat Rovira I Virgili, 43007 Tarragona, Spain[7]ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain[8]Department of Haematology and Medical Oncology,University Medical Center Göttingen, 37075 Göttingen Germany[9]Department of Diagnostic and Interventional Radiology, University Medical Center Göttingen, 37075 Göttingen Germany[10]Department of Molecular Biology of Neuronal Signals, Max-Planck-Institute for Experimental Medicine, 37075 Göttingen, Germany[11]California NanoSystems Institute,University of California, Los Angeles, Los Angeles, California 90095, United States[12]Department of Chemistry and Biochemistry,University of California, Los Angeles, Los Angeles, California 90095, United States[13]Department of Psychiatry and Semel Institute for Neuroscience and Human Behavior,University of California, Los Angeles, Los Angeles, California 90095, United States[14]Division of NanoMedicine and Center for the Environmental Impact of Nanotechnology,University of California, Los Angeles, Los Angeles, California 90095, United States[15]Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States[16]AA Nanomedicine & Nanotechnology Consultants, North Andover, Massachusetts 01845, United States[17]International School for Advanced Studies (SISSA/ISAS), 34136 Trieste, Italy[18]School of Chemistry & Bio21 Institute, University of Melbourne, Parkville, Victoria 3010, Australia[19]Department of Chemical and Pharmaceutical Sciences, University of Trieste, 34127 Trieste, Italy[20]CIC biomaGUNE, Paseo de Miramón 182, 20014, Donostia - San Sebastián, Spain[21]Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain[22]Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada[23]CAS Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China[24]School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798[25]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States[26]Molecular Imaging Program at Stanford and Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, California 94305, United States[27]Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electronical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China[28]Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, China[29]Instituto de Ciencia de Materiales de Sevilla. CSIC, Universidad de Sevilla, 41092 Seville, Spain[30]Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, 141 86 Stockholm, Sweden[31]Institute of Chemistry, Chinese Academy of Sciences, 100190 Beijing, China[32]Nanion, 80636 München, Germany[33]College of Polymer Science and Engineering, Sichuan University, 610000 Chengdu, China[34]Department of Materials Science and Engineering and A.J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States[35]Departments of Physics and Astronomy, Rice University, Houston, Texas 77005, United States[36]Departments of Materials Science and Engineering, Chemistry, and Medicine, Northwestern University, Evanston, Illinois 60208, United States[37]University Hospital, 4056 Basel, Switzerland[38]CLINAM, European Foundation for Clinical Nanomedicine, 4058 Basel, Switzerland[39]Department of Polymer Science and Engineering,Zhejiang University, 310027 Hangzhou, China[40]Center for Bionanoengineering and Department of Chemical and Biological Engineering, Zhejiang University, 310027 Hangzhou, China[41]Thoraxklinik Heidelberg, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany[42]The University of Tokyo, Bunkyo, Tokyo 113-8654, Japan[43]Havard University, Cambridge, Massachusetts 02139, United States[44]Biomedical Polymers Laboratory, University of Utah, Salt Lake City, Utah 84112, United States[45]Emergency Medicine, University of Michigan, Ann Arbor, Michigan 48019, United States[46]EMPA, Federal Institute for Materials Science and Technology, CH-9014 St. Gallen, Switzerland[47]Department of Molecular Medicine and Biopharmaceutical Sciences,Seoul National University, Seoul, South Korea[48]School of Chemical and Biological Engineering, Seoul National University, Seoul, South Korea[49]Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany[50]HIPS - Helmhotz Institute for Pharmaceutical Research Saarland, Helmholtz-Center for Infection Research, 66123 Saarbrücken, Germany[51]Department of Biomedical Engineering, Columbia University, New York City, New York 10027, United States[52]Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS), 100190 Beijing, China[53]Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine, Ciber-BBN, 20014 Donostia - San Sebastián, Spain[54]Laboratory of Bioengineering Regenerative Medicine (BioReM), Kazan Federal University, 420008 Kazan, Russia[55]Department of Interfaces, Max-Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany[56]Emory University, Atlanta, Georgia 30322, United States[57]Tokyo Women’s Medical University, Tokyo 162-8666, Japan[58]SMALL, Wiley-VCH, Weinheim, German[59]Advanced Institutes of Convergence Technology, Suwon, South Korea[60]Department of Chemistry, University of California, Irvine, California 92697, United States[61]Institut Català de Nanotecnologia, UAB, 08193 Barcelona, Spain[62]Vall d’Hebron University Hospital Institute of Research, 08035 Barcelona, Spain[63]Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States[64]Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States[65]Department of Molecular Biotechnology, University of Ghent, B-9000 Ghent, Belgium[66]Department of Materials, Department of Bioengineering, Institute for Biomedical Engineering, Imperial College London, London SW7 2AZ, United Kingdom[67]Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Hong Kong, China[68]Department of Chemical Engineering and Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu City, Taiwan, ROC 300[69]Institut für Organische Chemie, Universität Ulm, 89081 Ulm, Germany[70]Max-Planck-Institute for Polymer Research, 55128 Mainz, Germany[71]Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel[72]School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 430074 Wuhan, China[73]School of Pharmaceutical Science, Peking University, 100191 Beijing, China[74]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China[75]Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China
The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.
基金：
This work was supported by the Deutscher Akademischer
Austauschdienst (DAAD to Philipps Universität Marburg and
Zhejiang University, Hangzhou), the Chinesisch Deutsches
Zentrum für Wissenschaftsförderung (“CDZ” to Z.G. and
W.J.P.), and the Chinese Academy of Science (CAS). Part of
this work was supported by the National Natural Science
Foundation (51390481, 81227902, 81625011), National Basic
Research Program (2014CB931900) of China (to Y.S.), by the
European Commission grant Futurenanoneeds (to V.P. and
W.J.P.), by the Spanish Ministerio de Economia y Competitividad
(CTQ2011-23167 and CTQ2014-59808R to R.A.A.P.),
the Generalitat of Catalunya (2014-SGR-612 to R.A.A.P.), the
Deutsche Forschungsgemeinschaft (DFG) (AL552/8-1 to R.T.),
the Swiss National Science Foundation (NRP62 to P.H.), the
Claude & Julianna Foundation (grant to P.H.), the National
Science Foundation (NSF) grants CHE-1306928 (to R.P.) and
ECS-0601345; CBET 0933384; CBET 0932823; and CBET 1036672 (to N.A.K.), Canadian Institute of Health Research
(grant to W.C.W.C.), and Natural Sciences and Engineering
Research Council of Canada (grant to W.C.W.C.). S.A. and B.P.
acknowledge a fellowship from the Alexander von Humboldt
Foundation. N.F. acknowledges the Lars Hiertas Minne
Foundation. M.C. acknowledges Ikerbasque for a Research
Fellow position. X.C. acknowledges the Intramural Research
Program (IRP), National Institute of Biomedical Imaging and
Bioengineering (NIBIB), National Institutes of Health (NIH).
B.Z.T. acknowledges the Innovation and Technology Commission
of Hong Kong (ITC-CNERC14SC01). The Pancreatic
Cancer research of A.E.N. and H.M. was funded by the U.S.
National Cancer Institute, NIH grant # U01CA198846. A.E.
acknowledges Junta de Andalucía (Spain) for a Talentia Postdoc
Fellowship, co-financed by the European Union's Seventh
Framework Programme, grant agreement no 267226. A.G.S.
acknowledges support by BOF (UGent) and FWO (Research
Foundation Flanders). Part of this work was supported by the
National Natural Science Foundation of China (81625011).
通讯机构：[1]Fachbereich Physik,Philipps Universitat Marburg, 35037 Marburg, Germany[20]CIC biomaGUNE, Paseo de Miramón 182, 20014, Donostia - San Sebastián, Spain
推荐引用方式(GB/T 7714)：
Beatriz Pelaz,Christoph Alexiou,Ramon A. Alvarez-Puebla,et al.Diverse Applications of Nanomedicine.[J].ACS nano.2017,11(3):2313-2381.doi:10.1021/acsnano.6b06040.
APA：
Beatriz Pelaz,Christoph Alexiou,Ramon A. Alvarez-Puebla,Frauke Alves,Anne M. Andrews...&Wolfgang J. Parak.(2017).Diverse Applications of Nanomedicine..ACS nano,11,(3)
MLA：
Beatriz Pelaz,et al."Diverse Applications of Nanomedicine.".ACS nano 11..3(2017):2313-2381
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