机构：[1]The College of Clinical Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China,重庆医科大学附属第一医院[2]The College of Clinical Pediatrics, Chongqing Medical University, Chongqing, China,[3]Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, China,[4]Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China[5]The College of Basic Medical Sciences, Chongqing Medical University, Chongqing, China
To examine the association between small for gestational age (SGA) and inadequate gestational weight gain (GWG) in obese women (compared with Institute of Medicine [IOM] guidelines) stratified by obesity classes.
We conducted a meta-analysis of original researches with sufficient information about inadequate GWG in obese women stratified by obesity classes. SGA as the chief outcome was extracted and assessed in our analysis. MEDLINE and EMBASE were searched through Ovid from 28 May 2009 to 1 December 2015. Quality was assessed using a modified Newcastle-Ottawa scale.
480 citations were screened and 13 studies (437 512 obese women) were included. Obese women who gained weight below the guidelines had higher risks of SGA than those who gained weight within the guidelines (OR 1.28; 95% CI 1.14-1.43). The same conclusions were also confirmed in Class I, Class II and Class III of obese women: Class I (OR 1.37; 95% CI 1.22-1.54); Class II (OR 1.38; 95% CI 1.24-1.54); Class III (OR 1.25; 95% CI 1.14-1.36).
From our analysis, the guidelines of IOM can be applied to all the classes of obesity. More accurate boundaries for each obesity class should be established to evaluate the maternal and fetal risks. Diverse populations are thus necessary for more studies in the future.
基金：
Z.L.was supported byNature Science Foundation Project of
CQ (CSTC) (cstc2015jcyjBX0072), and the grant from the
National Nature Science Foundation of China (NSFC
31540019), Antibiotic Research and Reevaluation of Sichuan
Provincial Key Laboratory Topics (ARRLKF14-01),
Chongqing Medical University Basic Medical Science
Support Foundation (JC201514), and Chongqing Medical
University Research Cultivate Foundation (Natural Science)
(201417).
第一作者机构：[1]The College of Clinical Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China,
共同第一作者：
通讯作者：
通讯机构：[4]Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China[5]The College of Basic Medical Sciences, Chongqing Medical University, Chongqing, China
推荐引用方式(GB/T 7714)：
Zhou Xu,Zhenxing Wen,Yuhan Zhou,et al.Inadequate weight gain in obese women and the risk of small for gestational age (SGA): a systematic review and meta-analysis.[J].JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE.2017,30(3):357-367.doi:10.3109/14767058.2016.1173029.
APA：
Zhou Xu,Zhenxing Wen,Yuhan Zhou,Duanhua Li&Zhongli Luo.(2017).Inadequate weight gain in obese women and the risk of small for gestational age (SGA): a systematic review and meta-analysis..JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE,30,(3)
MLA：
Zhou Xu,et al."Inadequate weight gain in obese women and the risk of small for gestational age (SGA): a systematic review and meta-analysis.".JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 30..3(2017):357-367
