机构：[1]Department of Oral Maxillofacial-Head and Neck Oncology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[2]Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, China[3]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
The prognostic value of mucins expression in patients with head and neck cancer (HNC) remains controversial. To address this, a meta-analysis was performed to systematically evaluate prognostic significance of mucins expression in HNC. Electronic and manual searches were performed and a total of 20 studies including 2046 patients were selected for the final analysis. Increased mucins expression was associated with unfavorable overall survival in HNC patients (HR=1.83, 95% CI: 1.43-2.33, p=0.000). Mucins overexpression was also in correlation with more advanced TNM stage (RR=0.84, 95% CI: 0.73-0.97, p=0.017), higher risk of lymph node metastasis (RR=0.69, 95% CI: 0.57-0.84, p=0.000) and deeper invasion (RR=0.58, 95% CI: 0.44-0.76, p=0.000). These results suggested that elevated mucins expression was significantly associated with worse prognosis and more detrimental clinicopathological outcomes, revealing the promising potential of mucins as biomarkers for HNC management.
基金：
the Research Grants (16ZR1418800) from Science and Technology Commission of Shanghai Municipality.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Oral Maxillofacial-Head and Neck Oncology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[2]Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Oral Maxillofacial-Head and Neck Oncology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[2]Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, China
推荐引用方式(GB/T 7714)：
Lu Hao,Liang Dan,Zhu Yun,et al.Prognostic and clinicopathological significance of MUC expression in head and neck cancer: a systematic review and meta-analysis.[J].Oncotarget.2017,8(56):96359-96372.doi:10.18632/oncotarget.19648.
APA：
Lu Hao,Liang Dan,Zhu Yun,Xu Wanlin,Zhou Kaihua...&Yang Wenjun.(2017).Prognostic and clinicopathological significance of MUC expression in head and neck cancer: a systematic review and meta-analysis..Oncotarget,8,(56)
MLA：
Lu Hao,et al."Prognostic and clinicopathological significance of MUC expression in head and neck cancer: a systematic review and meta-analysis.".Oncotarget 8..56(2017):96359-96372
