机构：[1]Department of Hepato‑Biliary‑Pancrease, Institute of General Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 639000, P.R. China
The objective of the present study was to investigate the association between zinc finger protein (ZNF) 689 expression and the clinicopathological features and prognosis of hepatocellular carcinoma (HCC). A total of 102 paired HCC and paired non-cancerous tissues, and 16 normal liver tissues were collected. ZNF689 expression was examined in HCC tissues, paired-noncancerous tissues, and normal liver tissues using RT-qPCR and immunohistochemistry analysis, and the association between ZNF689 expression and HCC prognosis was analyzed using the Kaplan-Meier method. ZNF689 expression was not significantly different between HCC tissues and paired-noncancerous tissues (P=0.61). ZNF689 expression in HCC and paired-noncancerous tissues was significantly increased compared with that in normal liver tissues (P<0.01). Positive expression of ZNF689 protein in HCC was significantly associated with a tumor size of ≥10 cm, tumor capsule infiltration, and microvascular invasion (P<0.05). Positive expression of ZNF689 was a prognostic factor for overall survival time [hazard ratio (HR):1.961; P=0.048] and progression-free survival time (HR:1.902; P=0.041). ZNF689 maybe a novel predictor for prognosis of patients with HCC.
基金：
the National Natural Science Foundation of China (grant. no. 71673193), and the Key Technology Research and Development Program of the Sichuan Province (grant. no. 2015SZ0131).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Hepato‑Biliary‑Pancrease, Institute of General Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 639000, P.R. China
通讯作者：
通讯机构：[1]Department of Hepato‑Biliary‑Pancrease, Institute of General Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 639000, P.R. China[*1]Department of Hepato-Biliary-Pancrease, Institute of General Surgery, The Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong, Sichuan 639000, P.R. China
推荐引用方式(GB/T 7714)：
Yi Peng Sheng,Wu Bin,Deng Da Wei,et al.Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma.[J].Oncology letters.2018,16(4):5122-5130.doi:10.3892/ol.2018.9295.
APA：
Yi Peng Sheng,Wu Bin,Deng Da Wei,Zhang Guang Nian&Li Jian Shui.(2018).Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma..Oncology letters,16,(4)
MLA：
Yi Peng Sheng,et al."Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma.".Oncology letters 16..4(2018):5122-5130
