机构：[1]Department of Radiation Oncology, Peking University First Hospital, No.7Xishiku Street, Beijing 100034, People’s Republic of China[2]Department ofMedical and Pharmaceutical Science and Technology Strategy Research,Institute of Medical Information, Chinese Academy of Medical Sciences, No. 3Yabao Road, Beijing, China[3]Department of Thoracic Surgery, West ChinaSchool of Medicine/West China Hospital of Sichuan University, No. 37Guoxue Alley, Chengdu 610041, Sichuan, People’s Republic of China.
We performed a meta-analysis to compare the efficacy of definitive chemoradiotherapy (dCRT) and esophagectomy as initial treatments for potentially resectable esophageal cancer.
To assess both strategies, the combined odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Thirteen studies (N = 2071; dCRT = 869 and surgery = 1202) were included. In all, 90.39% of the patients were diagnosed with esophageal squamous cell carcinoma (ESCC).
The 2-year (OR = 1.199, 95% CI 0.922-1.560; P = 0.177) and 5-year overall survival (OS) rates (OR = 0.947, 95% CI 0.628-1.429; P = 0.796) were not significantly different. No significant differences were identified in the 2-year OS among patients with stage I disease (OR = 1.397, 95% CI 0.740-2.638; P = 0.303) or stage II-III (OR = 0.418, 95% CI 0.022-7.833; P = 0.560). Patients with lymph node metastases tended to have a better 5-year OS when treated with dCRT than with surgery (OR = 0.226, 95% CI 0.044-1.169; P = 0.076); however, the difference between the two methods was not significant. Western patients who received dCRT had poorer prognoses than patients who underwent surgery (OR = 1.522, 95% CI 1.035-2.238; P = 0.033). dCRT and surgery led to similar 5-year progression-free survival rates (OR = 1.06, 95% CI 0.79-1.42; P = 0.70).
dCRT and surgery are equally effective as initial treatments for potentially resectable esophageal cancer. These results apply primarily to Asian populations as they have an increased incidence of ESCC.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区肿瘤学4 区外科
最新[2023]版：
大类|3 区医学
小类|3 区肿瘤学3 区外科
第一作者：
第一作者机构：[1]Department of Radiation Oncology, Peking University First Hospital, No.7Xishiku Street, Beijing 100034, People’s Republic of China
通讯作者：
推荐引用方式(GB/T 7714)：
Ma Ming-Wei,Gao Xian-Shu,Gu Xiao-Bin,et al.The role of definitive chemoradiotherapy versus surgery as initial treatments for potentially resectable esophageal carcinoma.[J].World journal of surgical oncology.2018,16(1):172.doi:10.1186/s12957-018-1470-y.
APA：
Ma Ming-Wei,Gao Xian-Shu,Gu Xiao-Bin,Xie Mu,Cui Ming...&Chen Long-Qi.(2018).The role of definitive chemoradiotherapy versus surgery as initial treatments for potentially resectable esophageal carcinoma..World journal of surgical oncology,16,(1)
MLA：
Ma Ming-Wei,et al."The role of definitive chemoradiotherapy versus surgery as initial treatments for potentially resectable esophageal carcinoma.".World journal of surgical oncology 16..1(2018):172
