机构：[1]Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University.[2]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education.[3]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health.[4]Department of Pathology, West China Second University Hospital.[5]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
To evaluate the association between Foxp3 gene polymorphisms (rs3761548 and rs5902434) and susceptibility to endometrial cancer (EC), we report a hospital case-control study involving 602 women, consisting of 269 patients with EC and 333 healthy controls. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Our results suggest that the frequency of the A allele in rs3761548 in patients with EC was significantly lower than that in healthy controls (20.3% vs 26.4%, odds ratio [OR] 0.71, 95% confidence interval [CI]: 0.54-0.93, P = .012), while the heterozygous AC genotype showed a significant protective effect on EC in codominant, dominant, and overdominant models (adjusted OR 0.64, 95% CI: 0.45-0.91, P = .039; OR 0.65, 95% CI: 0.47-0.91, P = .011; OR 0.67, 95% CI: 0.47-0.94, P = .02, respectively), and AA genotype was more frequent in patients with cervical invasion (recessive model: OR 3.55, 95% CI: 1.10-11.44, P = .046). Moreover, ATT/ATT genotype (rs5902434) was conferred a lower risk of EC in the recessive model (adjusted OR 0.58, 95% CI: 0.35-0.96, P = .031). From the data generated, we conclude that Foxp3 promoter polymorphisms are associated with susceptibility to EC in Chinese Han women.
基金：
This work was supported by the National Natural Science Foundation of China
(No 81572573) and the Applied Basic Research Programs of Science and
Technology Commission Foundation of Sichuan Province (No 2016SZ0013,
2015SZ0054-2).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|3 区医学：内科
最新[2023]版：
大类|4 区医学
小类|4 区医学：内科
第一作者：
第一作者机构：[1]Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University.[2]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University.[2]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education.[3]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health.[5]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.[*1]Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China
推荐引用方式(GB/T 7714)：
You Di,Wang Yanyun,Zhang Yan,et al.Association of Foxp3 promoter polymorphisms with susceptibility to endometrial cancer in the Chinese Han women.[J].Medicine.2018,97(18):e0582.doi:10.1097/MD.0000000000010582.
APA：
You Di,Wang Yanyun,Zhang Yan,Li Qin,Yu Xiuzhang...&Xi Mingrong.(2018).Association of Foxp3 promoter polymorphisms with susceptibility to endometrial cancer in the Chinese Han women..Medicine,97,(18)
MLA：
You Di,et al."Association of Foxp3 promoter polymorphisms with susceptibility to endometrial cancer in the Chinese Han women.".Medicine 97..18(2018):e0582
