The Correlation Between the Immune and Epithelial-Mesenchymal Transition Signatures Suggests Potential Therapeutic Targets and Prognosis Prediction Approaches in Kidney Cancer.
机构：[1]Department of Urology, Institute of Urology,WestChina Hospital, Sichuan University,Chengdu, 610041, Sichuan, China.[2]Center ofGrowth, Metabolism, and Aging, Key Laboratory of Bio-Resources and Eco-Environment,College of Life Sciences, Sichuan University, Chengdu, 610064, Sichuan, China.
Both epithelial-mesenchymal transition (EMT) and immune regulation are important biological process in malignant tumours. The current research aims to comprehensively explore the potential association between the epithelial-mesenchymal transition (EMT) signature and immune checkpoint signature and its role in predicting the prognosis of clear-cell renal cell carcinoma (ccRCC) patients. EMT-related genes were collected from an experiment-based study and then were investigated using data from the Cancer Genome Atlas. A total of 357 genes were included, and 23 of them that were upregulated and correlated with prognosis were analysed further as core EMT genes in ccRCC. Interestingly, the emerging immune checkpoints CD276, OX40 and TGFB1 were found to be significantly co-expressed with core EMT genes, and TGFB1, CXCR4, IL10, and IL6 were the most important molecules potentially interacting with EMT molecules in our model, as determined from mRNA co-expression and protein-protein interaction network analysis. Additionally, an integrated scoring model based on FOXM1, TIMP1 and IL6 was successfully established to distinguish ccRCC patients with different clinical risks. Our results identified core genes in the EMT-immunophenotyping correlation and evaluated their risk assessment capabilities, providing more potential therapeutic targets and prediction approaches regarding the translational research of treatment and prognosis in ccRCC.
基金：
Tis work was supported by the Science and Technology Foundation of the Sichuan Province (2014JY0183 to Yiping Lu, 2016FZ0099 to Xin Wei and 2017SZ0123 to Zhi-hong Liu), the Science and Technology Foundation of
the Chengdu City (2014-HM01-00301-SF to Yi-ping Lu) and the 1.3.5 project for disciplines of excellence. West
China Hospital, Sichuan University. We also would like to thank TCGA project organizers as well as all study
participants.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
最新[2023]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
第一作者：
第一作者机构：[1]Department of Urology, Institute of Urology,WestChina Hospital, Sichuan University,Chengdu, 610041, Sichuan, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liang Jiayu,Liu Zhihong,Zou Zijun,et al.The Correlation Between the Immune and Epithelial-Mesenchymal Transition Signatures Suggests Potential Therapeutic Targets and Prognosis Prediction Approaches in Kidney Cancer.[J].Scientific reports.2018,8(1):6570.doi:10.1038/s41598-018-25002-w.
APA：
Liang Jiayu,Liu Zhihong,Zou Zijun,Tang Yongquan,Zhou Chuan...&Lu Yiping.(2018).The Correlation Between the Immune and Epithelial-Mesenchymal Transition Signatures Suggests Potential Therapeutic Targets and Prognosis Prediction Approaches in Kidney Cancer..Scientific reports,8,(1)
MLA：
Liang Jiayu,et al."The Correlation Between the Immune and Epithelial-Mesenchymal Transition Signatures Suggests Potential Therapeutic Targets and Prognosis Prediction Approaches in Kidney Cancer.".Scientific reports 8..1(2018):6570
