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γδ T cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury.

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收录情况： ◇ SCIE ◇ 自然指数

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机构： [1]The First Affiliated Hospital, Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering [2]Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory [3]The First Affiliated Hospital, Jinan University, Guangzhou, China [4]Co-Innovation Center of Neuroregeneration, Nantong University, Jiangsu, China [5]State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China [6]National Center for International Research of Biological Targeting Diagnosis and Therapy, Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, China [7]Key Laboratory of Neuroscience, School of Basic Medical Sciences, Institute of Neuroscience, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China

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Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). γδ T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in γδ T cells (TCRδ-/- ) showed improved functional recovery after SCI. γδ T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the Vγ4 subtype and express the inflammatory cytokine IFN-γ. Inactivating IFN-γ signaling in macrophages results in a significantly reduced production of proinflammatory cytokines in the cerebrospinal fluid (CSF) of mice with SCIs and improves functional recovery. Furthermore, treatment of SCI with anti-Vγ4 antibodies has a beneficial effect, similar to that obtained with anti-TNF-α. In SCI patients, γδ T cells are detected in the CSF, and most of them are IFN-γ positive. In conclusion, manipulation of γδ T cell functions may be a potential approach for future SCI treatment. © 2018 Sun et al.

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出版当年[2018]版：

大类 | 1 区

医学

小类 | 1 区免疫学 1 区医学：研究与实验

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区免疫学 1 区医学：研究与实验

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出版当年[2018]版：

Q1 IMMUNOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q1 IMMUNOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 12.8 最新[2023版] 14.2 最新五年平均 10.892 出版当年[2018版] 11.897 出版当年五年平均 10.79 出版前一年[2017版] 11.743 出版后一年[2019版]

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第一作者机构： [1]The First Affiliated Hospital, Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering

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通讯机构： [1]The First Affiliated Hospital, Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering [2]Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory [4]Co-Innovation Center of Neuroregeneration, Nantong University, Jiangsu, China [5]State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China [7]Key Laboratory of Neuroscience, School of Basic Medical Sciences, Institute of Neuroscience, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China

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