机构：[1]Department of Forensic Biology, West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China[2]Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China[3]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children’s Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China[4]Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China四川大学华西医院
Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. The present study was conducted to evaluate whether the TATC (rs71682980) and CAA (rs34917480) insertion/deletion polymorphisms of RTN4 3'-UTR are associated with clear cell renal cell carcinoma (ccRCC). These two polymorphisms were genotyped in 308 ccRCC patients and 466 healthy controls by polymerase chain reaction polyacrylamide gel electrophoresis (PCR-PAGE). Significantly reduced ccRCC risk was observed to be associated with the TATCins/ins genotype carriers (Versus TATCdel/del: adjusted OR 0.53, 95% CI 0.32-0.87, P = 0.022; Versus TATCdel/del-del/ins: adjusted OR 0.57, 95% CI 0.36-0.92, P = 0.017). After performing stratification analysis, the frequency of TATCins/ins genotype was observed to be significantly higher in patients with N0 compared the patients with N1 (P = 0.003). The present study provide evidence for the first time that the TATC insertion/deletion polymorphism in RTN4 3'-UTR may contributes to ccRCC risk in Chinese Han population.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区遗传学4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区遗传学4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Forensic Biology, West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Forensic Biology, West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China[3]Laboratory of Molecular Translational Medicine, West China Institute of Women and Children’s Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
推荐引用方式(GB/T 7714)：
Pu Yan,Chen Peng,Zhou Bin,et al.Association of genetic variations in RTN4 3'-UTR with risk for clear cell renal cell carcinoma.[J].Familial cancer.2018,17(1):129-134.doi:10.1007/s10689-017-0005-y.
APA：
Pu Yan,Chen Peng,Zhou Bin,Zhang Peng,Wang Yanyun...&Zhang Lin.(2018).Association of genetic variations in RTN4 3'-UTR with risk for clear cell renal cell carcinoma..Familial cancer,17,(1)
MLA：
Pu Yan,et al."Association of genetic variations in RTN4 3'-UTR with risk for clear cell renal cell carcinoma.".Familial cancer 17..1(2018):129-134
