机构：[1]Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA[2]UCD School of Medicine, College of Health and Agricultural Science and UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland[3]Department of Hematology, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[4]Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
Multiple myeloma (MM) is among the most compelling examples of cancer in which research has markedly improved the length and quality of lives of those afflicted. Research efforts have led to 18 newly approved treatments over the last 12 years, including seven in 2015. However, despite significant improvement in overall survival, MM remains incurable as most patients inevitably, yet unpredictably, develop refractory disease. Recent advances in high-throughput 'omics' techniques afford us an unprecedented opportunity to (1) understand drug resistance at the genomic, transcriptomic, and proteomic level; (2) discover novel diagnostic, prognostic, and therapeutic biomarkers; (3) develop novel therapeutic targets and rational drug combinations; and (4) optimize risk-adapted strategies to circumvent drug resistance, thus bringing us closer to a cure for MM. In this review, we provide an overview of 'omics' technologies in MM biomarker and drug discovery, highlighting recent insights into MM drug resistance gleaned from the use of 'omics' techniques. Moving from the bench to bedside, we also highlight future trends in MM, with a focus on the potential use of 'omics' technologies as diagnostic, prognostic, or response/relapse monitoring tools to guide therapeutic decisions anchored upon highly individualized, targeted, durable, and rationally informed combination therapies with curative potential.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区血液学4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区血液学4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA[2]UCD School of Medicine, College of Health and Agricultural Science and UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
通讯作者：
通讯机构：[1]Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA[4]Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland[*1]Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA[*2]Department of Haematology, Mater Misericordiae University Hospital, Dublin 7, Ireland
推荐引用方式(GB/T 7714)：
Guang Matthew Ho Zhi,McCann Amanda,Bianchi Giada,et al.Overcoming multiple myeloma drug resistance in the era of cancer 'omics'.[J].Leukemia & lymphoma.2018,59(3):542-561.doi:10.1080/10428194.2017.1337115.
APA：
Guang Matthew Ho Zhi,McCann Amanda,Bianchi Giada,Zhang Li,Dowling Paul...&Anderson Kenneth C.(2018).Overcoming multiple myeloma drug resistance in the era of cancer 'omics'..Leukemia & lymphoma,59,(3)
MLA：
Guang Matthew Ho Zhi,et al."Overcoming multiple myeloma drug resistance in the era of cancer 'omics'.".Leukemia & lymphoma 59..3(2018):542-561
