机构：[a]Department of Urology, Institute of Urology, West China Hospital, Sichuan University,四川大学华西医院[b]Department of Urology, The Third People’s Hospital of Chengdu/The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan, P. R. China.
Inflammatory myofibroblastic tumors of the urinary bladder (IMTUB) is exceptionally rare. Currently, no standardized treatment has been established for IMTUBs.
Herein we report three cases presenting with hematuria and anemia. A 25-year-old man experienced painless gross hematuria for 2 days and the hemoglobin level continuously dropped to 88 g/L; a 72-year-old man complaining of gross hematuria for seven days; and a 33-year-old woman presenting with gross hematuria, urgency, and frequency for the duration of 20 days, with a hemoglobin level of 61 g/L.
Ultrasonography, contrast-enhanced computed tomography (CT) scan and magnetic resonance image (MRI) indicated masses of different sizes on the walls of the urinary bladders. Diagnostic transurethral resection of bladder tumor (TURBT) was performed which revealed the diagnosis of IMTUB.
In our cases, we removed the tumors completely with a minimally invasive approach. The first patient received TURBT only. The other patients underwent further laparoscopic and robot-assisted laparoscopic partial cystectomy respectively for the incomplete resection of tumor by diagnostic TURBT.
Histology of the resected specimen had proliferation of spindle cells with inflammation consistent with IMTUB. Immunohistochemical staining revealed that the tumor cells were positive for anaplastic lymphoma kinase (ALK), Vimentin and Ki-67 (20%-40%), negative for smooth muscle actin (SMA), S-100 and desmin confirming the diagnosis of IMTUB. Follow-up cystoscopy and CT or MRI (mean follow-up period: two years) did not detect any local recurrence or distant metastasis.
Bladder-sparing treatment by TURBT or partial cystectomy remains the main mode of treatment for IMTUB. Laparoscopic and robot-assisted laparoscopic approach is safe and may yield satisfactory oncological and functional results. Regular follow-up protocol is necessary after operation.
基金：
This study was supported by National Natural Science Foundation of China (Grant No. 81370655, No. 81200551, No. 81300627, and No. 81500522), Health and
Family Planning Commission of Sichuan Province (Grant No. 18PJ462) and Chengdu Science and Technology Bureau (Grant No. 2018-YF05-00208-SN). The authors
acknowledged R. D. Tharaka Rajaguru for reviewing the manuscript.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|3 区医学：内科
最新[2023]版：
大类|4 区医学
小类|4 区医学：内科
第一作者：
第一作者机构：[a]Department of Urology, Institute of Urology, West China Hospital, Sichuan University,[b]Department of Urology, The Third People’s Hospital of Chengdu/The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan, P. R. China.
共同第一作者：
通讯作者：
通讯机构：[a]Department of Urology, Institute of Urology, West China Hospital, Sichuan University,[b]Department of Urology, The Third People’s Hospital of Chengdu/The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan, P. R. China.[*1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China[*2]Department of Urology, The Third People’s Hospital of Chengdu/The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan, P. R. China
推荐引用方式(GB/T 7714)：
He Xu,Ben He,Xiang Tu,et al.Minimally invasive surgery for inflammatory myofibroblastic tumor of the urinary bladder: Three case reports.[J].Medicine.2018,97(49):e13474.doi:10.1097/MD.0000000000013474.
APA：
He Xu,Ben He,Xiang Tu,Yige Bao,Lu Yang...&Qiang Wei.(2018).Minimally invasive surgery for inflammatory myofibroblastic tumor of the urinary bladder: Three case reports..Medicine,97,(49)
MLA：
He Xu,et al."Minimally invasive surgery for inflammatory myofibroblastic tumor of the urinary bladder: Three case reports.".Medicine 97..49(2018):e13474
