机构：[1]Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province,China四川大学华西医院[2]Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State Key Laboratory ofBiotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China四川大学华西医院[3]Division ofEpidemiology, Vanderbilt University Medical Center, Nashville, TN, United States of America[4]Departmentof Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China四川大学华西医院
The survival of pancreatic cancer patients with lesions in different locations is unclear. In addition, the different surgery types for nonmetastatic pancreatic head cancer (PHC) or body/tail cancer (PBTC) have different prognostic influences. We analyzed the association by stage between tumor location (head vs. body/tail) and survival of nonmetastatic pancreatic cancer patients who underwent surgery.
We identified stages I to III pancreatic cancer patients who underwent surgery from 2004 through 2015 by using the Surveillance, Epidemiology, and End Results (SEER) database. The adjusted hazard ratio (HR) and 95% confidence interval (CI) for cancer-specific survival (CSS) were obtained using Cox regression.
A total of 13517 patients or 86.6% had PHC. PHC patients were more likely to have an advanced tumor stage, higher tumor grade, and more frequent and a higher number of positive lymph nodes compared with PBTC patients. The PHC patients had a worse CSS than PBTC patients (P<0.001) and were predominantly at stage I (P = 0.008) and II (P = 0.004). Multivariate Cox regression analysis showed that PHC was an independent prognostic factor associated with a worse CSS in pancreatic cancer patients (HR 1.132, 95% CI 1.042-1.228, P = 0.003), predominantly at stage II (HR 1.128, 95% CI 1.030-1.235, P = 0.009).
At a resectable early stage, the PHC patients had a worse CSS than PBTC patients after surgery. PHC was an independent prognostic factor associated with worse survival in pancreatic cancer patients, predominantly at stage II.
基金：
This work was supported by the 1.3.5
project for disciplines of excellence-Clinical
Research Incubation Project, West China Hospital,
Sichuan University (Grant no. ZY2017302 1-3-5);
National Health and Family Planning Commission
of Chengdu (Grant no. 2016002); Key Research projects of Department of science and Technology
of Sichuan Province, China (Grant no.
2018SZ0403); and Popularization and Application
Project of Sichuan Health and Family Planning
Commission (Grant no. 18PJ387).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
最新[2023]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
第一作者：
第一作者机构：[1]Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province,China
通讯作者：
推荐引用方式(GB/T 7714)：
Zheng Zhenjiang,Wang Mojin,Tan Chunlu,et al.Disparities in survival by stage after surgery between pancreatic head and body/tail in patients with nonmetastatic pancreatic cancer.[J].PloS one.2019,14(12):e0226726.doi:10.1371/journal.pone.0226726.
APA：
Zheng Zhenjiang,Wang Mojin,Tan Chunlu,Chen Yonghua,Ping Jie...&Liu Xubao.(2019).Disparities in survival by stage after surgery between pancreatic head and body/tail in patients with nonmetastatic pancreatic cancer..PloS one,14,(12)
MLA：
Zheng Zhenjiang,et al."Disparities in survival by stage after surgery between pancreatic head and body/tail in patients with nonmetastatic pancreatic cancer.".PloS one 14..12(2019):e0226726
