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MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis.

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收录情况： ◇ SCIE

作者：
Liang Du[1,2,3,4] ; Lu Wang[1,2] ; Jinfeng Gan[2,3] ; Zhimeng Yao[2,3] ; Wan Lin[3] ; Junkuo Li[5,6] ; Yi Guo[7] ; Yuping Chen[8] ; Fuyou Zhou[5,6] ; Sai-Ching Jim Yeung[9,10] ; Robert P. Coppes[4] ; Dianzheng Zhang[11,12] ; Hao Zhang[1,2,13] ;
机构： [1]Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China [2]Institute of Precision Cancer Medicine and Pathology, Department of Pathology, Jinan University Medical College, Guangzhou, Guangdong 510632, China [3]Cancer Research Center, Shantou University Medical College, Shantou, Guangdong 515041, China [4]Department of Biomedical Sciences of Cells & Systems, Section Molecular Cell Biology and Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen 9700 AD, the Netherlands [5]The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang, Henan 455001, China [6]Department of Thoracic Surgery, Anyang Tumor Hospital, Anyang, Henan 455001, China [7]Endoscopy Center, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China [8]Department of Thoracic Surgery, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China [9]Department of Emergency Medicine, University of Texas MDAnderson Cancer Center, Houston, TX 77030, USA [10]Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MDAnderson Cancer Center, Houston, TX 77030, USA [11]Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131, USA [12]Key Laboratory of Epigenetics and Oncology, Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China [13]Research Centre of Translational Medicine, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515063, China
出处：
DOI： 10.1016/j.isci.2019.11.009

摘要：
Cancer cell stemness (CCS) plays critical roles in both malignancy maintenance and metastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA3low/SOX2high is associated with poor prognosis and could serve as an independent prognostic factor. These findings altogether indicate that MTA3/SOX2OT/SOX2 axis plays an indispensable role in CCS. Therefore, this axis could be potentially used in cancer stratification and serves as a therapeutic target. Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of China (Grant Nos. 81773087, 81071736, and 81572876 to H.Z.); the Science and Technology Planning Project of Guangdong Province of China (2019A030317024 to H.Z.); the Shantou University-Technion Research Program (Grant No. 43209504 to H.Z.); and the National Natural Science Foundation of China (grant No. 81802884 to J.G.). The authors thank Jiali Jiang, Xiurong Ke, Xiao Xiong, and other members of H.Z.’s laboratory for their experimental assistance and helpful discussion.
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外文
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无
最新[2023]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
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出版当年[2019]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China [2]Institute of Precision Cancer Medicine and Pathology, Department of Pathology, Jinan University Medical College, Guangzhou, Guangdong 510632, China [3]Cancer Research Center, Shantou University Medical College, Shantou, Guangdong 515041, China [4]Department of Biomedical Sciences of Cells & Systems, Section Molecular Cell Biology and Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen 9700 AD, the Netherlands
共同第一作者：
通讯作者：
通讯机构： [1]Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China [2]Institute of Precision Cancer Medicine and Pathology, Department of Pathology, Jinan University Medical College, Guangzhou, Guangdong 510632, China [5]The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang, Henan 455001, China [6]Department of Thoracic Surgery, Anyang Tumor Hospital, Anyang, Henan 455001, China [13]Research Centre of Translational Medicine, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515063, China
推荐引用方式(GB/T 7714)：
Liang Du,Lu Wang,Jinfeng Gan,et al.MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis.[J].ISCIENCE.2019,22:353-+.doi:10.1016/j.isci.2019.11.009.
APA：
Liang Du,Lu Wang,Jinfeng Gan,Zhimeng Yao,Wan Lin...&Hao Zhang.(2019).MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis..ISCIENCE,22,
MLA：
Liang Du,et al."MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis.".ISCIENCE 22.(2019):353-+

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