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Sedentary Behavior, Physical Activity, and All-Cause Mortality: Dose-Response and Intensity Weighted Time-Use Meta-analysis.

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资源类型：
Pubmed体系：
作者：
Xu Chang[1] ; Furuya-Kanamori Luis[2,3] ; Liu Yu[4] ; Færch Kristine[5] ; Aadahl Mette[6,7] ; A Seguin Rebecca[8,9] ; LaCroix Andrea[9] ; Basterra-Gortari F Javier[10] ; Dunstan David W[11,12] ; Owen Neville[11,13,14] ; Doi Suhail A R[2,*1] ;
机构： [1]Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu, China [2]Department of Population Medicine, College of Medicine, Qatar University, Doha, Qatar [3]Research School of Population Health, ANU College of Health and Medicine, Australian National University, Acton, Australia [4]Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, Gansu, China [5]Steno Diabetes Center Copenhagen, Gentofte, Denmark [6]Centre for Clinical Research and Prevention, Bispebjerg og Frederiksberg Hospital, Frederiksberg, Denmark [7]Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark [8]Division of Nutritional Sciences, Cornell University, Ithaca, NY [9]Fred Hutchinson Cancer Research Center, Seattle, WA [10]Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain [11]Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia [12]Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia [13]Swinburne University of Technology, Hawthorn, Victoria, Australia [14]Central Clinical School, Medicine, Monash University, Melbourne, Victoria, Australia
出处：
DOI： 10.1016/j.jamda.2019.05.001
ISSN：

关键词： Sedentary time physical activity all-cause mortality dose-response meta-analysis intensity-weighted time-use epidemiology

摘要：
Previous studies have placed those with excessive sedentary behavior at increased risk of all-cause mortality. There is evidence of interdependency of sedentary behavior with physical activity, and its elucidation will have implications for guidelines and practice. This study investigated if sedentary behavior-related mortality risk can be offset by moderate- to vigorous-intensity physical activity (MVPA) considered in a time-use fashion. PubMed was searched (from its inception till May 2018) for studies or meta-analyses that used data harmonized for MVPA. Of the 17 data-custodians located, 7 provided data on sitting time or TV viewing time, or both. A dose-response meta-analysis modeling log relative risks of all-cause mortality against uncompensated sedentary behavior metabolic equivalent hours (USMh) was run using the robust error meta-regression method. (Registration: CRD42017062439) SETTING: Individual subject data held by data custodians on this topic. General adults. Sedentary time, MVPA. Five harmonized cohorts of sitting time (258,688 participants) and 4 of TV viewing time (156,593 participants) demonstrated that sedentary behavior was significantly associated with mortality, but this risk was attenuated with increasing energy expenditure through MVPA modeled in a time-use fashion. The average increment in mortality per USMh spent on sitting was 1% [relative risk (RR) 1.01, 95% confidence interval (CI) 1.00, 1.02; P = .01] and that per USMh spent on TV viewing was 7% (RR 1.07, 95% CI 1.04, 1.10; P < .001). The thresholds for risk started at 7 USMh for sitting and 3 USMh for TV viewing. Our findings suggest that overall daily sitting time energy expenditure of 7 MET-hours (or TV viewing of 3 MET-hours) in excess of that expended on MVPA is independently related to all-cause mortality. These findings support the view that sitting is strongly influenced by consideration of concurrent MVPA in its impact on adverse health consequences and that the USMh is a more practical metric of sedentary behavior. Copyright © 2019 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

基金：
National Health and Medical Research Council (NHMRC) of Australia Early Career Fellowship (no. 1158469). N.O. is supported by a NHMRC Senior Principal Research Fellowship (no. 1003960), an NHMRC Centre for Research Excellence Grant (no. 1057608) and by the Victorian Government’s Operational Infrastructure Support Program. D.D. is supported by an NHMRC Senior Research Fellowship (no. 1078360), an NHMRC Centre for Research Excellence Grant (no. 1057608), and by the Victorian Government’s Operational Infrastructure Support Program. The Women’s Health Initiative (WHI) program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 2 区 医学
小类 | 2 区 老年医学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 老年医学
第一作者：
第一作者机构： [1]Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu, China
通讯作者：
通讯机构： [2]Department of Population Medicine, College of Medicine, Qatar University, Doha, Qatar [*1]Department of Population Medicine, College of Medicine, Qatar University, Al Jamiaa Street, P.O. Box 2713, Doha, Qatar
推荐引用方式(GB/T 7714)：
Xu Chang,Furuya-Kanamori Luis,Liu Yu,et al.Sedentary Behavior, Physical Activity, and All-Cause Mortality: Dose-Response and Intensity Weighted Time-Use Meta-analysis.[J].Journal of the American Medical Directors Association.2019,20(10):1206-1212.e3.doi:10.1016/j.jamda.2019.05.001.
APA：
Xu Chang,Furuya-Kanamori Luis,Liu Yu,Færch Kristine,Aadahl Mette...&Doi Suhail A R.(2019).Sedentary Behavior, Physical Activity, and All-Cause Mortality: Dose-Response and Intensity Weighted Time-Use Meta-analysis..Journal of the American Medical Directors Association,20,(10)
MLA：
Xu Chang,et al."Sedentary Behavior, Physical Activity, and All-Cause Mortality: Dose-Response and Intensity Weighted Time-Use Meta-analysis.".Journal of the American Medical Directors Association 20..10(2019):1206-1212.e3

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