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Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin.

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机构： [1]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, No.17, 3rd Section of People’s South Road, Chengdu 610041, China [2]Department of Nephrology,West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China [3]Department of Urinary Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China [4]Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, Cancer Institute & Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100034, China

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Daptomycin (DAP), a cyclic lipopeptide produced by Streptomyces roseosporus, is a novel antibiotic to clinically treat various Gram-positive pathogenic bacteria-induced infections. Although DAP has a strong broad-spectrum bactericidal effect, recently rare bacterial antibiotic resistance against DAP gradually arises. The review is to summarize the normal indications of DAP, its off-label usage against several clinical pathogen infections, the unique antibacterial mechanisms of DAP, and the combination of antibiotic therapies for highly DAP-resistant pathogens. More noticeably, rising evidences demonstrate that DAP has new potential activity of anticancer and immunomodulatory effects. So far the multifunctional pharmaceutical effects of DAP deserve to be further explored for future clinical applications.

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出版当年[2019]版：

大类 | 4 区生物学

小类 | 4 区生物工程与应用微生物 4 区医学：研究与实验

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第一作者机构： [1]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, No.17, 3rd Section of People’s South Road, Chengdu 610041, China

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