机构：[1]Department of Biomass Chemistry and Engineering Sichuan University Chengdu 610065 China.[2]Laboratory of Ethnopharmacology Regenerative Medicine Research Center West China Hospital Sichuan University Chengdu Sichuan 610041 China.四川大学华西医院[3]Wyss Institute for Biologically Inspired Engineering John A. Paulson School of Engineering and Applied Sciences Harvard University Boston MA 02115 USA.[4]Department of Environmental Science and Engineering College of Environment and Resources Fuzhou University Fuzhou 350108 China.[5]ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and Department of Chemical and Biomolecular Engineering The University of Melbourne Parkville Victoria 3010 Australia.[6]Department of Bioproducts and Biosystems School of Chemical Engineering Aalto University P. O. Box 16300 00076 Finland.[7]Department of Materials Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan.[8]National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan University Chengdu Sichuan 610065 China.
The targeted therapy of metastatic melanoma is an important yet challenging goal that has received only limited attention to date. Herein, green tea polyphenols, (-)-epigallocatechin-3-gallate (EGCG), and lanthanide metal ions (Sm3+) are used as building blocks to engineer self-assembled SmIII-EGCG nanocomplexes with synergistically enhanced tumor inhibitory properties. These nanocomplexes have negligible systemic toxic effects on healthy cells but cause a significant reduction in the viability of melanoma cells by efficiently regulating their metabolic pathways. Moreover, the wound-induced migration of melanoma cells can be efficiently inhibited by SmIII-EGCG, which is a key criterion for metastatic melanoma therapy. In a mouse melanoma tumor model, SmIII-EGCG is directly compared with a clinical anticancer drug, 5-fluorouracil and shows remarkable tumor inhibition. Moreover, the targeted therapy of SmIII-EGCG is shown to prevent metastatic lung melanoma from spreading to main organs with no adverse side effects on the body weight or organs. These in vivo results demonstrate significant advantages of SmIII-EGCG over its clinical counterpart. The results suggest that these green tea-based, self-assembled nanocomplexes possess all of the key traits of a clinically promising candidate to address the challenges associated with the treatment of advanced stage metastatic melanoma.
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外文
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中科院(CAS)分区：
出版当年[2019]版：
大类|1 区材料科学
小类|1 区材料科学：综合2 区化学综合2 区纳米科技
最新[2023]版：
大类|1 区材料科学
小类|1 区化学：综合1 区材料科学：综合2 区纳米科技
第一作者：
第一作者机构：[1]Department of Biomass Chemistry and Engineering Sichuan University Chengdu 610065 China.[2]Laboratory of Ethnopharmacology Regenerative Medicine Research Center West China Hospital Sichuan University Chengdu Sichuan 610041 China.
通讯作者：
通讯机构：[1]Department of Biomass Chemistry and Engineering Sichuan University Chengdu 610065 China.[3]Wyss Institute for Biologically Inspired Engineering John A. Paulson School of Engineering and Applied Sciences Harvard University Boston MA 02115 USA.[8]National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan University Chengdu Sichuan 610065 China.
推荐引用方式(GB/T 7714)：
Li Ke,Xiao Gao,Richardson Joseph J,et al.Targeted Therapy against Metastatic Melanoma Based on Self-Assembled Metal-Phenolic Nanocomplexes Comprised of Green Tea Catechin.[J].Advanced science (Weinheim, Baden-Wurttemberg, Germany).2019,6(5):1801688.doi:10.1002/advs.201801688.
APA：
Li Ke,Xiao Gao,Richardson Joseph J,Tardy Blaise L,Ejima Hirotaka...&Shi Bi.(2019).Targeted Therapy against Metastatic Melanoma Based on Self-Assembled Metal-Phenolic Nanocomplexes Comprised of Green Tea Catechin..Advanced science (Weinheim, Baden-Wurttemberg, Germany),6,(5)
MLA：
Li Ke,et al."Targeted Therapy against Metastatic Melanoma Based on Self-Assembled Metal-Phenolic Nanocomplexes Comprised of Green Tea Catechin.".Advanced science (Weinheim, Baden-Wurttemberg, Germany) 6..5(2019):1801688
材料科学