The accumulation of metabolic syndrome components is associated with higher risk of positive surgical margin among patients with localized prostate cancer after radical prostatectomy.
机构：[1]Department of Urology, Instituteof Urology, West China Hospital,Sichuan University, Chengdu, Sichuan,People’s Republic of China四川大学华西医院[2]Centerof Biomedical Big Data, West ChinaHospital, Sichuan University, Chengdu,Sichuan, People’s Republic of China[3]West China Medical School, SichuanUniversity, Chengdu, Sichuan, People’sRepublic of China四川大学华西医院
To evaluate the association between metabolic syndrome (MetS) and the accumulation of its components with prostate cancer (PCa).
Patients undergoing radical prostatectomy were retrospectively included. Patients were grouped by low risk and intermediate-high risk according to International Society of Urological Pathology grade. Multivariable logistic regression and Cox hazard regression model were utilized to assess the association of MetS with overall survival, biochemical recurrence, upgrading, upstaging, and positive surgical margin (PSM) after prostatectomy. Besides, trend test was also performed to evaluate the impact of the accumulation of MetS components on postoperative pathological feature.
A total of 1,083 patients were eventually enrolled. With a median follow-up of 40.45 months, 197 patients were diagnosed with MetS. No significant association between MetS and survival outcomes and pathological features was found. However, we did notice that the accumulation of the MetS components could lead to an elevated gradient of the PSM risk in the entire cohort (one component: OR=1.46; two components: OR=1.89; ≥3 components: OR=2.07; P for trend=0.0194) and intermediate-high risk group (one component: OR=1.4; two components: OR=1.85; ≥3 components: OR=2.05; P for trend=0.0127).
The accumulation of MetS components could lead to increasing risk of PSM on the entire PCa cohort and patients with intermediate-high risk PCa after prostatectomy, but not for the low-risk patients.
基金：
This work was supported by the National Key
Research and Development Program of China (Grant No.
SQ2017YFSF090096), the Prostate Cancer Foundation
Young Investigator Award 2013, the National Natural
Science Foundation of China (Grant Nos 81300627,
81370855, 81702536, and 81770756), Programs from Science
and Technology Department of Sichuan Province (Grant
Nos 2014JY0219 and 2017HH0063), and Young Investigator
Award of Sichuan University 2017.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区生物工程与应用微生物4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|3 区生物工程与应用微生物4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Urology, Instituteof Urology, West China Hospital,Sichuan University, Chengdu, Sichuan,People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Urology, Instituteof Urology, West China Hospital,Sichuan University, Chengdu, Sichuan,People’s Republic of China[*1]Department of Urology, West China Hospital, Institute of Urology, Sichuan University, No 37, Guoxue Alley, Chengdu 610041, Sichuan, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zheng Xiaonan,Qiu Shi,Liao Xinyang,et al.The accumulation of metabolic syndrome components is associated with higher risk of positive surgical margin among patients with localized prostate cancer after radical prostatectomy.[J].OncoTargets and therapy.2019,12:1613-1620.doi:10.2147/OTT.S195148.
APA：
Zheng Xiaonan,Qiu Shi,Liao Xinyang,Han Xin,Jin Kun...&Wei Qiang.(2019).The accumulation of metabolic syndrome components is associated with higher risk of positive surgical margin among patients with localized prostate cancer after radical prostatectomy..OncoTargets and therapy,12,
MLA：
Zheng Xiaonan,et al."The accumulation of metabolic syndrome components is associated with higher risk of positive surgical margin among patients with localized prostate cancer after radical prostatectomy.".OncoTargets and therapy 12.(2019):1613-1620
