机构：[1]Department of Neurosurgery and Institute of Neurosurgery, State Key Lab of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China四川大学华西医院[2]Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
α-Mangostin (αM), a traditional natural product with promising application of treating a series of diseases, was limited use in clinical due to its hydrophobicity. Herein, MPEG-PCL nanomicelles were used to embed the αM for resolving hydrophobicity and improving the anti-melanoma effect of the αM. The anti-melanoma activity and potential mechanisms of biodegradable αM/MPEG-PCL nanomicelles were investigated. The αM/MPEG-PCL nanomicelles possessed a stronger effect on anti-melanoma compared to the free αM both in vitro and in vivo with a low cytotoxicity in non-tumor cell lines. In the research of mechanisms, the αM/MPEG-PCL nanomicelles inhibited the proliferation of melanoma cell, induced apoptosis via both apoptosis pathways of intrinsic and exogenous in vitro, as well as suppressed tumor growth and restrained angiogenesis in vivo, which implied that the αM/MPEG-PCL nanomicelles have potential application as a novel chemotherapeutic agent in melanoma therapy.
基金：
This work was supported by the National Natural Science Foundation of China
(NSFC81502165), Ministry of Science and Technology of the People’s Republic
of China (2018ZX09201018-005) and Guangdong Innovative Research Team
Program (No. 2011Y073).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|2 区生物学
小类|2 区细胞生物学
最新[2023]版：
大类|1 区生物学
小类|2 区细胞生物学
第一作者：
第一作者机构：[1]Department of Neurosurgery and Institute of Neurosurgery, State Key Lab of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Shuping Yang,Xiang Gao,Yihong He,et al.Applying an innovative biodegradable self-assembly nanomicelles to deliver α-mangostin for improving anti-melanoma activity.[J].Cell death & disease.2019,10(3):146.doi:10.1038/s41419-019-1323-9.
APA：
Shuping Yang,Xiang Gao,Yihong He,Yuzhu Hu,Bocheng Xu...&Yongmei Xie.(2019).Applying an innovative biodegradable self-assembly nanomicelles to deliver α-mangostin for improving anti-melanoma activity..Cell death & disease,10,(3)
MLA：
Shuping Yang,et al."Applying an innovative biodegradable self-assembly nanomicelles to deliver α-mangostin for improving anti-melanoma activity.".Cell death & disease 10..3(2019):146
生物学