机构：[1]Department of Gastrointestinal Surgery., West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[2]West China Clinical Research Center of Breast Disease., West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[3]Department of Pathology., West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[4]Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院
Tenascin-C (TNC), an extracellular matrix glycoprotein, has been implicated in progression of various types of cancer. However, few reports exist on TNC expression in gastrointestinal stromal tumors (GISTs). We here attempted to investigate the expression pattern and prognostic significance of TNC in gastric GISTs. We studied TNC expression in 122 gastric GISTs tissue samples by immunohistochemistry, and examined the correlations of TNC expression with clinicopathological parameters and survival of gastric GISTs. The TNC-high expression was observed in 30 (24.6%) of 122 of gastric GISTs. The high levels of TNC expression in gastric GISTs was significantly associated with tumor size (P < .001), multivisceral resection (P = .006), metastasis at initial diagnosis (P = .006), mitotic count (P = .002) and NIH risk classification (P = .015). The TNC mRNA and protein levels were found to significantly downregulated in tumors without progression compared to those tumors which occurred tumor progression during the follow-up period (P < .05). As for the prognostic analysis, it revealed that tumor size, mitotic count, surgical margins, multivisceral resection, and TNC expression were independent predictors of PFS for gastric GISTs (P < .05). The overexpression of TNC may be as a possible marker for the metastatic potential of gastric GISTs patients.
基金：
National Natural Science Foundation of China(No. 81572931).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|3 区医学：内科
最新[2023]版：
大类|4 区医学
小类|4 区医学：内科
第一作者：
第一作者机构：[1]Department of Gastrointestinal Surgery., West China Hospital, Sichuan University, Chengdu, Sichuan, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Gastrointestinal Surgery., West China Hospital, Sichuan University, Chengdu, Sichuan, China.[4]Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.[*1]Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China[*2]Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041 Sichuan, China
推荐引用方式(GB/T 7714)：
Shen Chaoyong,Wang Chengshi,Yin Yuan,et al.Tenascin-C expression is significantly associated with the progression and prognosis in gastric GISTs.[J].Medicine.2019,98(2):e14045.doi:10.1097/MD.0000000000014045.
APA：
Shen Chaoyong,Wang Chengshi,Yin Yuan,Chen Huijiao,Yin Xiaonan...&Zhou Zongguang.(2019).Tenascin-C expression is significantly associated with the progression and prognosis in gastric GISTs..Medicine,98,(2)
MLA：
Shen Chaoyong,et al."Tenascin-C expression is significantly associated with the progression and prognosis in gastric GISTs.".Medicine 98..2(2019):e14045
