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64Cu-labeled Melanin nanoparticles for PET/CT and radionuclide therapy of tumor.

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收录情况： ◇ SCIE ◇ EI

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机构： [a]Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China [b]Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, CA, USA [c]Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, China [d]Department of Gastrointestinal Surgery, West China Forth Hospital, Sichuan University, Chengdu, Sichuan, China [e]Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China [f]Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China [g]The Affiliated Shanxi Bethune Hospital of Shanxi Medical University, The Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan, China

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关键词： Melanin nanoparticles 64Cu PET/CT Imaging agent Radionuclide therapy

摘要：

Melanin is a group of natural pigments found in living organism. It can be used for positron emission tomography (PET) imaging due to its inherent chelating ability to radioactive cupric ion. This study was to prepare 64Cu-labeled PEGylated Melanin nanoparticles (64Cu-PEG-MNPs), and to further take advantage of the enhanced permeability and retention (EPR) effect of radiolabeled nanoparticles to realize the integration of tumor diagnosis and treatment. We successfully synthesized PEG-MNPs. Saline and serum stability experiments demonstrating good stability. PET/CT showed high tumor aggregation. Moreover, 64Cu-PEG-MNPs resulted in a therapeutic effect on the A431 tumor-bearing mice in the treatment group. The pathological results further confirmed that the therapeutic doses of 64Cu-PEG-MNPs cause pathological changes of tumor tissues while showing minimal toxicity to normal tissues. Our data successfully demonstrate the good imaging performance of 64Cu-PEG-MNPs on A431 tumors and further proved its therapeutic effect, highlighting a great potential in targeted radionuclide therapy. Copyright © 2020. Published by Elsevier Inc.

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出版当年[2020]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q2 NANOSCIENCE & NANOTECHNOLOGY

最新[2023]版：

Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 4.2 最新[2023版] 5 最新五年平均 6.458 出版当年[2020版] 7.072 出版当年五年平均 5.182 出版前一年[2019版] 6.458 出版后一年[2021版]

第一作者：

第一作者机构： [a]Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China [b]Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, CA, USA

通讯作者：

通讯机构： [b]Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, CA, USA [*1]Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, Stanford, CA 94305-5484, USA.

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