机构：[a]Department of Gastroenterology, Tongde Hospital of Zhejiang Province,[b]Hospital of Chengdu University of Traditional Chinese Medicine, Sichuan Province,[c]Digestive Disease Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Zhejiang Province, China.
Chronic atrophic gastritis (CAG) is defined as an important precancerous disease in the development of gastric cancer. Early intervention of CAG is of great significance in reducing symptoms and blocking its progression to gastric cancer. Weifuchun (WFC) tablet is a classic Chinese patent medicine used to treat CAG. However, there is no systematic review related to WFC for atrophic gastritis published in English. we will conduct systematic review and meta-analysis to provide more evidence on the effectiveness and safety for clinical use of WFC.
Three English database and 4 Chinese databases will be searched from its inception to April 2020. Two trained researchers will independently select the qualified studies for data extraction and assess the quality and risk of bias. Then the meta-analyses will be performed by using the RevMan 5.2 and stata 14.0. The heterogeneity of data will be investigated by Cochrane X and I tests. Sensitivity analysis will be conducted to evaluate the stability of the results. A funnel plot analysis and Egger's test will be drawn to assess the publication bias. Finally, we will use the Grading of Recommendations Assessment, Development and Evaluate system to evaluate the methodological quality.
The results of our research will be published in a peer-reviewed journal.
The conclusion of our systematic review will provide evidence to judge whether WFC is an effective intervention for patient with CAG.
10.17605/OSF.IO/2UTMB.
基金：
This research was supported by the National science and technology major
special projects for the major new drug innovation (No. 2016ZX09101069) and
the 13th 5-Year Plan of Zhejiang Provincial Key Discipline Construction of
Traditional Chinese Medicine (No. 2017-XK-B02).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区医学：内科
最新[2023]版：
大类|4 区医学
小类|4 区医学：内科
第一作者：
第一作者机构：[a]Department of Gastroenterology, Tongde Hospital of Zhejiang Province,
共同第一作者：
通讯作者：
通讯机构：[a]Department of Gastroenterology, Tongde Hospital of Zhejiang Province,[c]Digestive Disease Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Zhejiang Province, China.[*1]Department of Gastroenterology, Tongde Hospital of Zhejiang Province, No.234 Gucui Road, Xihu District, Hangzhou City, 310012, China
推荐引用方式(GB/T 7714)：
Liangjun Yang,Zhipeng Hu,Jiajie Zhu,et al.Effects of weifuchun tablet for chronic atrophic gastritis: A protocol for systematic review and meta-analysis.[J].Medicine.2020,99(22):e20374.doi:10.1097/MD.0000000000020374.
APA：
Liangjun Yang,Zhipeng Hu,Jiajie Zhu&Baoying Fei.(2020).Effects of weifuchun tablet for chronic atrophic gastritis: A protocol for systematic review and meta-analysis..Medicine,99,(22)
MLA：
Liangjun Yang,et al."Effects of weifuchun tablet for chronic atrophic gastritis: A protocol for systematic review and meta-analysis.".Medicine 99..22(2020):e20374
