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The Biogenesis, Biology, and Clinical Significance of Exosomal PD-L1 in Cancer.

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机构： [1]Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. [2]Department of Colorectal Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. [3]Central Laboratory, The Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, China. [4]College of Computer and Information Engineering, Hunan University of Technology and Business, Changsha, China. [5]The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China. [6]Urban Vocational College of Sichuan, Chengdu, China. [7]Department of Radiotherapy, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

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关键词： exosomal PD-L1 biogenesis immunosuppression T cells biomarker immunotherapy

摘要：

The exosome serves as a trafficking vehicle for transport of programmed death-ligand 1 (PD-L1) into receptor cells. In tumor microenvironment, distant tumor cells can remotely attack activated T cells by exosomal PD-L1. Here, we summerize the biogenesis and transport process of exosomal PD-L1. Then, we focus on the cancer biology of exosomal PD-L1 in immunosuppression and the mechanism by which it inhibits T cells. Finally, we highlight the prospects of exosomal PD-L1 as a tumor biomarker and its significance in immunotherapy. In addition, we discuss the new challenges faced in researching and utilizing exosomal PD-L1. This review may shed light on the exosomal PD-L1 from the bench to the clinic. Exosomes serve as trafficking vehicles for transport of programmed death-ligand 1 (PD-L1) into receptor cells. In tumor microenvironment, distant tumor cells can remotely attack activated T cells through exosomal PD-L1. Here, we have summarized the biogenesis and transport of exosomal PD-L1. Next, we focused on the cancer biology of exosomal PD-L1 in immunosuppression and the mechanism by which it inhibits T cells. Finally, we highlighted the prospects of exosomal PD-L1 as a tumor biomarker and its significance in immunotherapy. In addition, we have discussed the new challenges faced in studying and utilizing exosomal PD-L1. This review may shed light on the translation of exosomal PD-L1 from bench to clinic. Copyright © 2020 Tang, Zhang, Wang, Wang, Su, Wang, Zhou, Zhou, Xiong, Zeng, Zhou, Nie and Liao.

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出版当年[2020]版：

大类 | 2 区

医学

小类 | 3 区免疫学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区免疫学

第一作者：

第一作者机构： [1]Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. [2]Department of Colorectal Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. [3]Central Laboratory, The Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, China.

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通讯作者：

通讯机构： [1]Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. [2]Department of Colorectal Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. [3]Central Laboratory, The Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, China.

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The Biogenesis, Biology, and Clinical Significance of Exosomal PD-L1 in Cancer.

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