详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 [2]Center for Oral and Systemic Diseases, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 [3]Oral and Craniofacial Biomedicine Program, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 [4]Department of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 [5]Doctor of Dental Surgery Program, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 [6]Division of Biostatistics and Computational Biology, University of Iowa College of Dentistry, Iowa City, IA 52242 [7]Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242 [8]Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA 52242 [9]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China [10]Center for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA 02142 [11]Department of Dental Ecology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 [12]Department of Periodontics and Oral Medicine, Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109

出处：

DOI：

ISSN：

摘要：

Emerging evidence suggests comprehensive immune profiling represents a highly promising, yet insufficiently tapped approach to identify potentially prognostic signatures for periodontitis. In this report, we agnostically identified a periodontitis-associated inflammatory expression network with multiple biomarkers identified within gingival crevicular fluid samples from study participants by applying principal component analysis. We identified an IL-17-dominated trait that is associated with periodontal disease and is inversely modified by the level of IL-10. IL-10 mitigated chemokine CXCL5 and CXCL1 expressions in IL-17-stimulated peripheral blood monocytic cells and peripheral blood monocytic cell-derived macrophages. Il10-deficient mice presented more bone loss, which was associated with more Il17 and IL-17-mediated chemokine and cytokine expression at the transcriptional levels in comparison with control wild-type mice in both the Porphyromonas gingivalis-induced experimental murine periodontitis and ligature-induced alveolar bone-loss models. The dampening effect of IL-10 on the excessive signaling of IL-17 appeared to be mediated by innate immune cells populations rather than by gingival epithelial cells, which are the major cell target for IL-17 signaling. Additionally, elevated IL-17 response in Il10-deficient mice specifically elicited an M1-skewing macrophage phenotype in the gingiva that was associated with the advanced bone loss in the ligature model. In summary, IL-17 dominated an inflammatory network characteristic of periodontitis, and IL-10 dampens this excessive IL-17-mediated periodontitis trait. Copyright © 2020 by The American Association of Immunologists, Inc.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版：

大类 | 2 区

医学

小类 | 2 区免疫学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区免疫学

第一作者：

第一作者机构： [1]Department of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 [2]Center for Oral and Systemic Diseases, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 [3]Oral and Craniofacial Biomedicine Program, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

通讯作者：

通讯机构： [7]Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242 [8]Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA 52242 [*1]Department of Periodontics, University of Iowa College of Dentistry, N401 Dental Science Building, 801 Newton Road, Iowa City, IA 52242.

推荐引用方式(GB/T 7714)：

APA：

MLA：