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Knockout of Stat5 in T cells ameliorates high cholesterol and high fat diet-induced hypercholesterolemia by influencing cholesterol metabolism in the liver.

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收录情况: ◇ SCIE ◇ CSCD-C ◇ 卓越:领军期刊

机构: [1]Model Animal Research Center of Nanjing University, 210061 Nanjing, China [2]Department of Biology, Southern University of Science and Technology, 518055 Shenzhen, China [3]West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China [4]Cancer Science Institute of Singapore, Singapore 117599, Singapore [5]Life Sciences Institute, NationalUniversity of Singapore, Singapore 117456, Singapore [6]The Seventh Affiliated Hospital, Sun Yat-sen University, 518107 Shenzhen, China [7]BGI-Shenzhen, 518083 Shenzhen,China [8]Vascular Surgery Department, Changhai Hospital, 200433 Shanghai, China [9]Navy Medical University, Yangpu District, Shanghai, China
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INTRODUCTION Cholesterol is an essential component of cell barrier formation and signal transduction and is involved in many essential physiologic processes.1 Dysregulation of cholesterol metabolism leads to hypercholesterolemia, which causes multiple diseases, including atherosclerosis.2 The liver plays a central role in cholesterol homeostasis by cholesterol synthesis, as well as clearance, which is regulated by sterol regulatory element-binding proteins (SREBPs) and the reverse cholesterol transport (RCT) process.3,4

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出版当年[2020]版:
大类 | 1 区 医学
小类 | 1 区 免疫学
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大类 | 1 区 医学
小类 | 1 区 免疫学
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Q1 IMMUNOLOGY
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Q1 IMMUNOLOGY

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第一作者机构: [1]Model Animal Research Center of Nanjing University, 210061 Nanjing, China [2]Department of Biology, Southern University of Science and Technology, 518055 Shenzhen, China [3]West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China
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通讯机构: [1]Model Animal Research Center of Nanjing University, 210061 Nanjing, China [2]Department of Biology, Southern University of Science and Technology, 518055 Shenzhen, China [3]West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China [4]Cancer Science Institute of Singapore, Singapore 117599, Singapore [5]Life Sciences Institute, NationalUniversity of Singapore, Singapore 117456, Singapore
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