详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Ligand-Installed Nanocarriers toward Precision Therapy.

文献详情

资源类型：

Pubmed体系：

收录情况： ◇ EI ◇ 自然指数

作者：

机构： [1]Department of Radiology, Center for Medical Imaging, and State Key Laboratory, of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No.17 People’s South Road, Chengdu 610041, China [2]Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan [3]Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan [4]Institute for Future Initiatives, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

出处：

DOI：

ISSN：

关键词： active targeting blood–brain barrier cancer nanoparticles precision therapy

摘要：

Development of drug-delivery systems that selectively target neoplastic cells has been a major goal of nanomedicine. One major strategy for achieving this milestone is to install ligands on the surface of nanocarriers to enhance delivery to target tissues, as well as to enhance internalization of nanocarriers by target cells, which improves accuracy, efficacy, and ultimately enhances patient outcomes. Herein, recent advances regarding the development of ligand-installed nanocarriers are introduced and the effect of their design on biological performance is discussed. Besides academic achievements, progress on ligand-installed nanocarriers in clinical trials is presented, along with the challenges faced by these formulations. Lastly, the future perspectives of ligand-installed nanocarriers are discussed, with particular emphasis on their potential for emerging precision therapies. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版：

大类 | 1 区

材料科学

小类 | 1 区化学综合 1 区物理化学 1 区纳米科技 1 区材料科学：综合 1 区物理：应用 1 区物理：凝聚态物理

最新[2023]版：

大类 | 1 区

材料科学

小类 | 1 区化学：综合 1 区物理化学 1 区材料科学：综合 1 区纳米科技 1 区物理：应用 1 区物理：凝聚态物理

第一作者：

第一作者机构： [1]Department of Radiology, Center for Medical Imaging, and State Key Laboratory, of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No.17 People’s South Road, Chengdu 610041, China

通讯作者：

通讯机构： [3]Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan [4]Institute for Future Initiatives, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Chronic cerebral hypoperfusion and blood-brain barrier disruption in uninjured brain areas of rhesus monkeys subjected to transient ischemic stroke. [2]Dual-targeting tigecycline nanoparticles for treating intracranial infections caused by multidrug-resistant Acinetobacter baumannii [3]Focused ultrasound-mediated blood-brain barrier opening combined with magnetic targeting cytomembrane based biomimetic microbubbles for glioblastoma therapy [4]Customizing delivery nano-vehicles for precise brain tumor therapy [5]Establishing a clinically relevant orthotopic xenograft model of patient-derived glioblastoma in zebrafish. [6]Intestinal dysbiosis exacerbates susceptibility to the anti-NMDA receptor encephalitis-like phenotype by changing blood brain barrier permeability and immune homeostasis [7]Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Mouse Glioblastoma Model [8]The Potential of Nano Pharmaceuticals to Change the Paradigm of Brain Tumor Therapy: A State-of-the-Art Review [9]Overcoming the On-Target Toxicity in Antibody-Mediated Therapies via an Indirect Active Targeting Strategy [10]Corrigendum to 'Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Mouse Glioblastoma Model' [Ultrasound in Med & Biol. 49 (2023) 1082-1090