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Ligand-Installed Nanocarriers toward Precision Therapy.

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机构： [1]Department of Radiology, Center for Medical Imaging, and State Key Laboratory, of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No.17 People’s South Road, Chengdu 610041, China [2]Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan [3]Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan [4]Institute for Future Initiatives, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

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关键词： active targeting blood–brain barrier cancer nanoparticles precision therapy

摘要：

Development of drug-delivery systems that selectively target neoplastic cells has been a major goal of nanomedicine. One major strategy for achieving this milestone is to install ligands on the surface of nanocarriers to enhance delivery to target tissues, as well as to enhance internalization of nanocarriers by target cells, which improves accuracy, efficacy, and ultimately enhances patient outcomes. Herein, recent advances regarding the development of ligand-installed nanocarriers are introduced and the effect of their design on biological performance is discussed. Besides academic achievements, progress on ligand-installed nanocarriers in clinical trials is presented, along with the challenges faced by these formulations. Lastly, the future perspectives of ligand-installed nanocarriers are discussed, with particular emphasis on their potential for emerging precision therapies. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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出版当年[2020]版：

大类 | 1 区

材料科学

小类 | 1 区化学综合 1 区物理化学 1 区纳米科技 1 区材料科学：综合 1 区物理：应用 1 区物理：凝聚态物理

最新[2023]版：

大类 | 1 区

材料科学

小类 | 1 区化学：综合 1 区物理化学 1 区材料科学：综合 1 区纳米科技 1 区物理：应用 1 区物理：凝聚态物理

第一作者：

第一作者机构： [1]Department of Radiology, Center for Medical Imaging, and State Key Laboratory, of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No.17 People’s South Road, Chengdu 610041, China

通讯作者：

通讯机构： [3]Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan [4]Institute for Future Initiatives, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

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